Computational Biology and Health Genomics
1988 Ph.D. in Statistics. Universitat de Barcelona. (Spain).
1988-1993 Postdoctoral researcher at the Molecular Biology Computer Research Resource. Dana Farber Cancer Institute, Harvard University (Division of Biostatistics) BioMolecular Engineering Research Center. Boston University and Theoretical Biology and Biophysics Group (Los Alamos National Laboratory).
1994-2010 Investigator at Institut Municipal d’Investigació Mèdica (IMIM). Barcelona, (Spain).
2001-2005 Associate Professor at the Universitat Pompeu Fabra. Barcelona, (Spain).
2001-2022 Coordinator of the Bioinformatics Programme at the Centre de Regulació Genòmica, Barcelona, (Spain).
Since 2005 Professor at the Universitat Pompeu Fabra. Barcelona, (Spain).
Epigenome mapped in detail across human body (30/03/2023)
An international research collaboration has addressed this challenge by cataloguing the human epigenome in unprecedented detail, charting the whole collection of epigenomic marks in more than 25 different types of tissues across the human body.
‘Space bacteria’ set to land in Barcelona (16/03/2023)
A new collaboration between the CRG and yuri GmbH, a commercial space biotechnology company in Germany, will bring together researchers to harness the power of microgravity conditions in space and study its impact on human health, cells, and plant biology.
Seasonal and circadian genetic variation charted across the human body (13/02/2023)
A research team at the CRG have published research in PLOS Biology which details how the circadian and circannual cycles influence humans at the molecular level by measuring changes to the activity of genes inside cells across different types of tissues.
CRG joins international efforts to protect human health from effects of harmful chemicals (11/03/2021)
Roderic Guigó will lead the CRG's contributions to the international consortium
CRG signs biodiversity genomic sequencing agreement with Andorra (01/03/2021)
This is the first time the country has been involved in a project of this magnitude
Small but ubiquitous sex differences in gene expression in human tissues linked to body fat, cancer, and birth weight (10/09/2020)
A study published today in Science reveals that biological sex has a small but ubiquitous influence on gene expression in almost every type of human tissue.
Human body mostly composed of just five major groups of cell (30/07/2020)
Scientists around the world have today published the results of the third phase of the Encyclopedia of DNA Elements (ENCODE) in Nature.
A study describes the dynamics of chromatin during organ and tissue regeneration (04/12/2018)
Researchers discover the genes and regulatory elements of their expression that are required during the process of tissue and organ regeneration in the fruit fly. The article appears highlighted in the cover of the Genome Research journal in December.
Roderic Guigó and Toni Gabaldón among the most highly cited researchers in the world (30/11/2018)
Two CRG group leaders are among the most highly cited researchers in the world, according to the list established by Clarivate Analytics.
Roderic Guigó receives the National Research Award (19/10/2018)
Roderic Guigó, coordinator of the CRG Bioinformatics and Genomics Programme, received the National Research Award. The award ceremony took place at the National Theatre of Catalonia in Barcelona on 15th October and it was chaired by the President of the Catalan Government, Mr. Quim Torra.
Gene expression patterns may help determine time of death (13/02/2018)
International team of scientists led by CRG programme coordinator Roderic Guigó shows that changes in gene expression in different tissues can be used to predict the time of death of individuals.
National Research Award 2017 to Roderic Guigó (27/12/2017)
Roderic Guigó, coordinator of the CRG Bioinformatics and Genomics Programme, honored with the highest recognition for research excellence in Catalonia.
A new method accelerates the mapping of genes in the “Dark Matter” of our DNA (06/11/2017)
Scientists at the Centre for Genomic Regulation (CRG) in Barcelona, have developed a new method, which improved the most important catalogue of genes -GENCODE-, including characterization of new genes in the DNA “Dark Matter”.
Genome Editing: Pressing the «Delete» Button on DNA (02/03/2017)
Until recently, genomics was a «read-only» science. But scientists led by Rory Johnson at the University of Bern and the Centre for Genomic Regulation in Barcelona, have now developed a tool for quick and easy deletion of DNA in living cells. This software will boost efforts to understand the vast regions of non-coding DNA, or «Dark Matter», in our DNA and may lead to discovery of new disease-causing genes and potential new drugs.
Spanish scientists sequence the genome of the Iberian lynx, the most endangered felid (14/12/2016)
Genomic analysis of the Iberian lynx confirms that it is one of the species with the least genetic diversity among individuals, which means that it has little margin for adaptation.
The Blueprint project celebrates major manuscript release (18/11/2016)
BLUEPRINT scientists, including researchers at the Centre for Genomic Regulation, release a collection of 25 publications in Cell, Cell Press-associated and other high-impact journals. These are part of a package of 41 publications by the International Human Epigenome Consortium (IHEC) of which BLUEPRINT is a member.
'Blueprint' study of epigenetics of blood cells will serve biology and medicine (07/09/2016)
Researchers from the EU-funded BLUEPRINT project join their international colleagues this week at the 2016 International Human Epigenome Consortium (IHEC) conference in Brussels to report the latest results in understanding blood cell development and blood disease.
CRG researchers contribute to the sequencing of the Turbot genome (09/03/2016)
The first vertebrate to be genetically sequenced in Spain, the Turbot (Scophthalmus maximus), has a much more refined visual system than other fish as it has evolved to adapt to the shortage of light of the seabed. In addition, the fat in its cell membranes are far higher than in other species to withstand the low water temperatures in its habitat.
The mesoamerican bean genome decoded (25/02/2016)
An Ibero-American team of scientists decoded the Mesoamerican variety of the bean genome coinciding with the celebration of the International Year of Pulses, as designated by the United Nations.
The "VEIS-Valorisation of EGA for Industry and Society" (VEIS-001-P-001647) project is cofunded by the European Regional Development Fund of the European Union in the framework of the ERDF Operative Program of Catalonia 2014-2020, with a grant of 1,951,429.38 EUR, with the support of the Department of Research and Universities of the Government of Catalonia.
The project “MAPAS GENETICOS Y EPIGENETICOS A LO LARGO DE LA FILOGENIA EUCARIOTA” (PID2021-128956NB-I00) is funded by Agencia Estatal de Investigación (AEI), the Ministerio de Ciencia e Innovación and Fondo Europeo de Desarrollo Regional (FEDER). Project PID2021-128956NB-I00 funded by MCIN/ AEI / 10.13039/501100011033 / FEDER, UE
The 'IMPaCT' project, with official reference IMP/00019, has been granted by the ISCIII, under the Infraestructura de Medicina de Precisión asociada a la Ciencia y Tecnología (IMPaCT) - Ciencia de Datos Call, the Spanish Ministry of Science and Innovation, and cofunded with ERDF Funds from the European Union.
Period: 01/01/2021 to 31/12/2023
The project 'Omplint el buit del mercat del single cell', granted under the call from 'Industria del Coneixement (Llavor i Producte), has received funding from the Department of Research and Universities, of the Government of Catalonia
Period: 19/10/2022 to 18/04/2024
The project “GENCODE: comprehensive reference genome annotation for human and mouse” has been granted by the NATIONAL INSTITUTE OF HEALTH – NIH with reference 2U24HG007234-09 .
Period: 14/09/2021 to 30/06/2025
The project 'Long-TREC: The Long-Reads Transcriptomics European Consortium. The next generation transcriptome biology revealed by single molecule sequencing technologies' has received funding from the European Union's HORIZON-MSCA-2021-DN-01-01 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 101072892.
Period: 01/10/2022 to 30/09/2026
Ref.: Marie Sklodowska-Curie grant agreement No 101072892
Datasets and resources
AStalavista, the Alternative Splicing Transcriptional Landscape Visualization Tool.
AStalavista, the Alternative Splicing Trascriptional Landscape Visualization Tool and more, retrieves all alternative splicing events from generic transcript annotations.
compmerge is a program that tries to solve the same problem as cuffmerge. It is not limited to cufflinks/stringtie models and transcripts, but can work with any GTF file. It merges the spliced transcripts that have a compatible intron structure and merges the monoexonic transcripts based on simple stranded overlap.The output is a GTF file of merged transcripts.
A combinatorial code for CPE-mediated translational control - the web server -
Given a 3'UTR sequence, the CPE-mediated translational control web server predicts the class of translational control behavior the corresponding mRNA belongs to.
The classification is done according to the combinatorial code for translational regulation discovered by Pique et al.
CRISPETa is a flexible tool to design optimal pairs of sgRNAs for deletion of desired genomic regions.
CRISPETa is a flexible tool to design optimal pairs of sgRNAs for deletion of desired genomic regions. These target regions can be supplied in BED or UCSC format. CRISPETa can be run on any number of targets - from one to thousands.
The transcriptome project aims to sequence various cell lines, and within those cell lines, different compartments, and RNA fractions, using different technologies.
GEM-Tools is a C API and a Python module to support and simplify usage of the GEM Mapper (https://bio.tools/tool/crg.eu/The%20GEM%20%28GEnome%20Multi-tool%29%20Li...)
Geneid is an ab initio gene finding program used to predict genes along DNA sequences in a large set of organisms.
Geneid is an ab initio gene finding program used to predict genes along DNA sequences in a large set of organisms. The program can be run through a web server (http://genome.crg.es/software/geneid/geneid.html) or downloaded and executed by command line
GenNon-h is a software designed to generate multiple sequence alignments of DNA evolving on any phylogenetic tree.
gff2aplot is a program to visualize the alignment of two sequences together with their annotations.
Input for the program consists of single or multiple files in GFF-format which specify the alignment coordinates and annotation features of both sequences. Output is in PostScript format of any size. The features to be displayed are highly customizable to meet user specific needs. The program serves to generate print-quality images for comparative genome sequence analysis.
gff2ps is a program for visualizing annotations of genomic sequences.
gff2ps is a program for visualizing annotations of genomic sequences. The program takes the annotated features on a genomic sequence in GFF format as input, and produces a visual output in PostScript. While it can be used in a very simple way, it also allows for a great degree of customization through a number of options and/or customization files.