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CRG Scientific Sessions

CRG Scientific SessionsCRG Scientific Sessions

18/03/202412:00R_473.10_AULABioinformatics and Genomics ProgrammeCarlo MaleyArizona Cancer and Evolution Center (University of Arizona)"The Evolution of Cancer Suppression Across Species"Host: Carbonell García, Rut

19/03/202412:00R_473.10_AULACell and Developmental Biology ProgrammePierre BercierCollege de France"How does arsenic cure acute promyelocytic leukemia ?".Host: Benito Mestres, MartaAbstract:Abstract :
PML (ProMyelocytic Leukemia) nuclear bodies are membrane-less organelles that play a pivotal role in cell biology by regulating the post-translational modifications of client proteins. Remarkably, these organelles are disrupted in the most aggressive form of leukemia: acute promyelocytic leukemia. Arsenic cures 70% of these patients as a single agent by enforcing PML nuclear bodies reassembly. However, despite being the frontline therapy, the molecular mechanisms underlying arsenic-induced cure of this leukemia remained...

19/03/202412:00R_473.10_AULACell and Developmental Biology ProgrammePierre BercierCollège de France“How does arsenic cure acute promyelocytic leukemia ?”Host: Benito Mestres, MartaAbstract:Abstract :
PML (ProMyelocytic Leukemia) nuclear bodies are membrane-less organelles that play a pivotal role in cell biology by regulating the post-translational modifications of client proteins. Remarkably, these organelles are disrupted in the most aggressive form of leukemia: acute promyelocytic leukemia. Arsenic cures 70% of these patients as a single agent by enforcing PML nuclear bodies reassembly. However, despite being the frontline therapy, the molecular mechanisms underlying arsenic-induced cure of this leukemia remained surprisingly...

20/03/202411:30R_473.10_AULABioinformatics and Genomics ProgrammeNoor YoussefHarvard Medical School“Protein design for future proof vaccines”Host: Bernardes Pereira de Figueiredo Dias, MafaldaAbstract:Abstract: Recurrent waves of SARS-CoV-2 infection, driven by the periodic emergence of new viral variants, highlight the need for vaccines and therapeutics that remain effective against future strains. Yet, our ability to proactively evaluate such therapeutics is limited to assessing their effectiveness against previous or circulating variants, which may differ significantly in their antibody escape from future viral evolution. To address this challenge, we develop a deep learning method to predict the effect of mutations on fitness and...

21/03/202412:00R_473.10_AULAPRBB Computational Genomics SeminarsAnamaria ElekSebé Lab.Host: Carbonell García, Rut

26/03/202412:00MARIE CURIEPRBB-CRG SessionsKivanç BirsoyLaboratory of Metabolic Regulation and Genetics, Rockefeller University"Understanding the role of oxidative metabolism in physiology and cancer"Host: Elvan BökeAbstract:Mitochondria must maintain adequate amounts of metabolites for protective and biosynthetic functions. However, how mitochondria sense the abundance of metabolites and regulate metabolic homeostasis is not well understood. Here, we will discuss glutathione (GSH), a critical redox metabolite in mitochondria, and our identification of a feedback mechanism that controls its abundance through the...

26/03/202412:00RAMÓN Y CAJALGene Regulation,Stem Cells&Cancer Progr.Prof. Donald C. RioUniversity of California at Berkeley"Neurodegenerative Diseases, RNA Binding Proteins and Alternative pre-mRNA Splicing"Host: Valcárcel Juárez, Juan

02/04/202412:00CHARLES DARWINBioinformatics and Genomics ProgrammeHeather MachadoWelcome Sanger Institut“Somatic evolution of the adaptive immune system in health and disease”Host: Benito Mestres, Marta

03/05/202412:00MARIE CURIEPRBB-CRG SessionsJoshua BrickmanNovo Nordisk Foundation Center for Stem Cell Medicine, reNEW Copenhagen"tbc"Host: Sergi Aranda

10/05/202412:00PRBB AuditoriumPRBB-CRG SessionsSteven GygiHarvard Medical School"Proteomics as a biological assay"Host: Eduard SabidóAbstract:Proteomics is the systematic analysis of proteins for their various properties including expression levels, modification state, structure, interaction partners, function, and many more. For protein expression profiling, the combination of mass spectrometry with sample multiplexing creates a unique biological assay where replicates, positive and negative controls, as well as all treatment conditions can be measured in a single experiment. Tandem mass tags (TMT) facilitate these analyses and will soon be...

17/05/202412:00MARIE CURIEPRBB-CRG SessionsFrank BradkeDZNE German Center for Neurodegenerative Diseases"Mechanisms of Axon Growth and Regeneration"Host: Thomas SurreyAbstract:Almost everybody who has seen neurons under a microscope for the first time is fascinated by their beauty and their complex shape. Early on during development, however, neurons look round and simple without signs of their future complexity. How do neurons develop their sophisticated structure? How do they initially generate domains that later have distinct functions within neuronal circuits, such as the axon? And, can a...

07/06/202412:00MARIE CURIEPRBB-CRG SessionsArnaud KrebsEuropean Molecular Biology Laboratory (EMBL)"tbc"Host: Renee Beekman

14/06/202412:00MARIE CURIEPRBB-CRG SessionsJan LammerdingMeinig School of Biomedical Engineering, Cornell University"tbc"Host: Verena Ruprecht

28/06/202412:00MARIE CURIEPRBB-CRG SessionsMagda BienkoHuman Technopole and Karolinska Institute"Long-distance communication between long and short neuronal genes mediated by RNA"Host: Renée Beekman & Victoria NeguemborAbstract:Intronic sequences are spliced out of newly transcribed RNAs and are usually rapidly degraded. Because of their rapid degradation, intronic RNAs have been classically viewed as splicing by-products. Here, we integrate genome-wide maps of RNA-DNA contacts measured by RADICL-seq with genome radiality maps obtained by GPSeq, to illuminate the spatial distribution and fate of intronic RNAs in the...

05/07/202412:00MARIE CURIEPRBB-CRG SessionsAndrea CossarizzaUniversità degli Studi di Modena e Reggio Emilia"tbc"Host: Oscar Fornas

12/07/202412:00MARIE CURIEPRBB-CRG SessionsMaurizio ScaltritiAstraZeneca, Oncology R&D"tbc"Host: Luciano di Croce