CRG Scientific Sessions
12/09/202415:00RAMÓN Y CAJALTechnical SeminarLisa MooreBioinformatics Research Group, Information and Computing Sciences Division, SRI InternationalBioCyc TutorialHost: Carbonell García, Rut
13/09/202412:00MARIE CURIEPRBB-CRG SessionsBen RaphaelPrinceton University"Quantifying tissue organization in space and time"Host: Donate WeghornAbstract:Tissues contain multiple cell types whose spatial arrangement facilitates specific biological functions. Recent spatial transcriptomics technologies measure RNA expression at thousands of locations in a 2D tissue slice quantifying the spatial distribution of cell types and spatial variation in gene expression. Due to limitations in technology and cost, these measurements are typically sparse with high rates of missing data. I will present algorithms that overcome these technical limitations by...
18/09/202411:00CHARLES DARWINGene Regulation,Stem Cells&Cancer Progr.Lay Teng AngAssistant Professor Stanford School of Medicine, Stanford UniversityDeveloping the Cellular Building Blocks from Human iPSCs to Generate Tissues and Organs and Their Susceptibility to Deadly Viruses."Host: Tagliaferro, Barbara
20/09/202412:00MARIE CURIEPRBB-CRG SessionsLaurent BlanchoinUniversité Grenoble-Alpes, CEA, CNRS, INRA & Université Paris Sciences et Lettres, CEA, ESPCI"Reconstituting the Dynamic Steady States of Actin Networks"Host: Adel Al Jord & Thomas SurreyAbstract:Intracellular organization is largely mediated by actin turnover. Cellular actin networks continuously assemble and disassemble while maintaining their overall structure. This behavior, called dynamic steady state, allows cells to sense and adapt to their environment. We developed reconstituted systems in vitro to mimic steady-state conditions with either unlimited or limited amounts of components, establishing feedback...
27/09/202412:00MARIE CURIEPRBB-CRG SessionsMariano BarbacidCentro Nacional de Investigaciones Oncológicas"Targeting KRAS Driven Cancers: A Reality after 40 Years"Host: Juan ValcarcelAbstract:KRAS oncogenes are responsible for a quarter of lung adenocarcinomas, half of colorectal carcinomas and most pancreatic tumors. First identified in 1982, they were considered undruggable until a decade ago when Shokat and co-workers identified a druggable pocket within the 3D structure of tKRAS that led to the generation and subsequent approval in June of 2021 of sotorasib, a selective inhibitor against the KRASG12C oncogenic isoform. Since then, several inhibitors capable of blocking other KRAS...
01/10/202410:00R_473.10_AULAGene Regulation,Stem Cells&Cancer Progr.Eunjung Alice LeeDivision of Genetics and Genomics, Boston Children’s Hospital; Department of Pediatrics, Harvard Medical School, BostonUSAstonMultifaceted Role of Retrotransposons in Human CancerHost: Tagliaferro, Barbara
24/10/202415:00CHARLES DARWINOther SeminarsJeffrey ChaoFriedrich Miescher Institute for Biomedical Research/ University of ValenciaImaging the life and death of mRNAs in single cellsHost: Tagliaferro, Barbara
25/10/202412:00MARIE CURIEPRBB-CRG SessionsIrene Miguel-AliagaThe Francis Crick Institute"The sex and geometry of organs"Host: Juan ValcarcelAbstract:I am interested in how information is encoded at the multi-organ level. Working at the interface between physiology and developmental biology, we have explored the “continued development” of adult organs. We have sought to understand how and why organs such as the intestine grow, shrink and are metabolically remodelled even in adult, fully developed animals, and how this plasticity differs between the sexes. We have tackled these questions across biological scales, initially in Drosophila and more...
13/12/202412:00MARIE CURIEPRBB-CRG SessionsMatthew Vander HeidenKoch Institute for Integrative Cancer Research at MIT"tbc"Host: Elvan Böke & Talya Dayton (EMBL)