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CRG Scientific Sessions

CRG Scientific SessionsCRG Scientific Sessions

09/02/202312:00R_473.10_AULAPRBB Computational Genomics SeminarsJudith Pérez GranadoLaura Furlong Group"Genetic associations on major depression: curation and functional analysis"Host: Guigó Serra, Roderic

14/02/202315:00MARIE CURIEOther SeminarsAngus I. LamondCentre for Gene Regulation & Gene Expression, School of Life Sciences, University of Dundee, UK"Molecular analysis of human diversity and its impact on drug discovery using iPS cells"Abstract:The impact of normal genetic diversity in human populations is important for understanding many aspects of health, disease and patient responses to drugs and therapeutics. Modern ‘omics’ and imaging technologies, can provide invaluable insights, at a systems level, into cell physiology and phenotypes relevant to both health and disease. I will describe our recent work and resulting insights from characterizing, in depth, the genomes, proteomes...

15/02/202312:00R_473.10_AULACell and Developmental Biology ProgrammeDr. Ignasi RoigFacultat de Biocències I Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona.“Mechanisms that regulate the ovarian reserve in mammals”Host: Böke, ElvanAbstract:Most reproduction problems in western societies are linked to women's fertility declines with age. This is partly caused by how mammalian eggs are formed. Women are born with a limited pool of follicles containing future eggs. This so-called ovarian reserve will be used during every woman's reproductive lifespan to produce fertilizable eggs. Thus, female fertility ends once this pool of follicles falls below a certain threshold (in humans, ~1000 primordial follicles)....

23/02/202315:00UPFSystems Biology ProgrammeXavier HernándezSerrano Lab."Translational control by differential expression of tRNAs"Host: Bartomeus Cistaré, Magalí

03/03/202312:00MARIE CURIEPRBB-CRG SessionsKonrad HochedlingerDept of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, USA"Transcriptional & epigenetic mechanisms that maintain cell identity"Host: Bernhard PayerAbstract:Chromatin modifications dynamically change with development and differentiation and their dysregulation underlies diseases such as cancer. However, our understanding of the functional roles these modifications play during these processes remains incomplete because of the redundancy of most histone modifying enzymes and the frequent toxicity of the respective knockout models. To overcome these...

08/03/202312:00R_473.10_AULAGene Regulation,Stem Cells&Cancer Progr.Dr Pradeepa MadapuraBlizard Institute, Queen Mary University of London"Role of H4K16ac in the regulation of vertebrate genome"Host: Payer, Bernhard

10/03/202312:00MARIE CURIEPRBB-CRG SessionsAndrea CalifanoColumbia University Medical Center, Herbert Irving Cancer Research Center, New York, USA"Bringing single cell analyses to the clinics"Host: Pia CosmaAbstract:We have developed network-based methodologies for the systematic identification, validation, and pharmacological targeting of a new class of therapeutic targets. These targets comprise Master Regulator proteins, whose concerted activity within a Regulatory Checkpoint module is responsible for the mechanistic implementation and maintenance of cell transcriptional state, in both transformed and non-transformed cells. By leveraging these methodologies, we have...

17/03/202312:00MARIE CURIEPRBB-CRG SessionsCarsten JankeInstitut Curie, Paris, France"tbd"Host: Thomas Surrey

14/04/202312:00R_473.10_AULAPRBB-CRG SessionsGonçalo Castelo-BrancoKarolinska Institutet, Stockholm, Sweden"tbd"Host: Sergi Aranda

21/04/202312:00MARIE CURIEPRBB-CRG SessionsSophie DumontDept. of Bioengineering and Therapeutic Sciences, Dept. of Biochemistry and Biophysics, UCSF, San Francisco, USA"tbd"Host: Thomas Surrey

26/05/202312:00MARIE CURIEPRBB-CRG SessionsDavid M. GilbertLaboratory of Chromosome Replication and Epigenome Regulation, San Diego Biomedical Research Institute, CA, USA"Regulation of Replication Timing and Chromosome Architecture"Host: Roderic GuigóAbstract:The mammalian genome is replicated in a defined temporal sequence during S phase of each cell cycle known as the replication timing program. Since chromatin is assembled at the replication fork, and different types of chromatin are assembled at different times, replication timing is positioned to be central to maintenance or alteration of chromatin states. We have found that replication timing is a highly stable cell-type...

16/06/202312:00MARIE CURIEPRBB-CRG SessionsHenrique Veiga-FernandesImmunophysiology Group, Champalimaud Centre for the Unknown, Lisbon, Portugal"tbd"Host: Pia Cosma

07/07/202312:00MARIE CURIEPRBB-CRG SessionsDirk SchubelerFMI, Basel, Switzerland"tbd"Host: Renee Beekman

15/12/202312:00MARIE CURIEPRBB-CRG SessionsCeline VallotInstitut Curie, Paris, France"tbd"Host: Renee Beekman