CRG Scientific Sessions
27/01/202212:00OnlinePRBB Computational Genomics SeminarsJose Carlos MontañésEvolutionary Genomics (Mar Albà's group), GRIB-IMIMNew genes and alternative isoforms detected with Oxford Nanopore direct RNAHost: Garrido Enamorado, RominaAbstract:click the link below to join the webinar:
Oxford Nanopore Technologies (ONT) direct RNA (dRNA) sequencing offers several important advantages over previous RNA-Seq approaches: each long sequencing read corresponds to a single mRNA molecule, it is possible to estimate poly(A) tail length, and one can obtain information on RNA modifications. In the present...
28/01/202212:00RAMÓN Y CAJALGene Regulation,Stem Cells&Cancer Progr.Panagiota Kafasla, PhDInstitute for Fundamental Biomedical Research. Vari, Greece"Why one should M-ind the IQ-GAP1 in splicing"Host: Pérez González, Gemma
03/02/202212:00OnlinePRBB Computational Genomics SeminarsSuzanne JinComparative Bioinformatics (Notredame's lab, CRG)Towards a composition-aware analysis of gene expression dataHost: Garrido Enamorado, RominaAbstract:Link to connect:
Compositional data containing only relative abundances are common in life sciences. A well-known example is the count data generated from sequencing experiments: the read counts are constrained by an arbitrary total sum (i.e. library size) that varies depending on external factors like sequencing depth. Consequently, the expression of a gene in different samples...
04/02/202212:00CHARLES DARWINPRBB-CRG SessionsPhilippe CluzelDept. of Molecular and Cellular Biology, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, USA"Simplicity in Biology as a guiding principle: Designing drug cocktails for resistant microbes, cancer cells, and vaccines"Host: Thomas SurreyAbstract:There exist two distinct approaches to developing predictive models in biology. The first approach is to provide a detailed molecular description of cellular systems, which lets you identify the key mechanisms that underlie complex phenotypes. The second approach relies on the systems’ macroscopic properties rather than on the...
11/02/202212:00CHARLES DARWINPRBB-CRG SessionsElizabeth TranDepartment of Biochemistry, Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA"Unraveling the Role of DDX5 in Small Cell Lung Cancer: Lessons from Basic Model Systems to In Vivo Models"Host: Juan ValcárcelAbstract:Small cell lung cancer (SCLC) accounts for more than 30,000 cases per year in the United States. Although this represents a small fraction (15%) of total lung cancer cases, SCLC stands apart from the more common, non-small cell lung cancer due to its rapid metastasis, high mortality rate (9-month median survival),...