Scientific sessions of the PRBB centres funded by the Centre for Genomic Regulation (CRG) and the Barcelona Biomedical Research Park
28/06/201912:00MARIE CURIEPRBB-CRG SessionsNancy J. CoxDivision of Genetics, Department of Medicine, Vanderbilt University Medical Center, US"Using Improved Genetic Prediction of Gene Expression in a Biobank to Explore Pleiotropy"Host: Roderic Guigó (CRG)Abstract:There have been several approaches proposed for improving the genetic
prediction of transcript levels, and our most recent approach provides
significantly better out-of-sample prediction performance than the
original PrediXcan model, TWAS models that have been described, and
UTMOST. We use a generalized model that takes advantage of both ENCODE
annotations and the...
05/07/201912:00MARIE CURIEPRBB-CRG SessionsDavid GarfliedHumboldt University Berlin, DE"Characterising the functional consequences of non-coding mutations using single-cell ATAC-Seq in non-human model systems"Host: Arnau Sebé-PedrosAbstract:Many of the mutations that define us – the ones that make us tall vs. short or healthy vs. sick and even the mutations that make us human, are found distributed across the non-coding, regulatory genome. Identifying and characterizing these mutations, however is challenging; unlike coding loci, the locations and function of DNA regulatory elements cannot typically be determined by DNA sequence alone. Regulatory elements are also highly...
12/07/201912:00MARIE CURIEPRBB-CRG SessionsTrisha WittkoppU-M LSA Ecology and Evolutionary Biology (EEB), USA"Effects of mutation and selection on gene expression"Host: PhD StudentsAbstract:Molecular mechanisms regulating gene expression play critical roles in development, physiology, and evolution. In this seminar, I will discuss how cis- and trans-acting factors controlling transcription vary within and between species and how new mutations affect these regulatory mechanisms. The impact of selection on this regulatory variation will also be discussed.