PRBB-CRG Sessions
Scientific sessions of the PRBB centres funded by the Centre for Genomic Regulation (CRG) and the Barcelona Biomedical Research Park
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30/10/202612:00MARIE CURIEPRBB-CRG SessionsEmmanuel DeriveryMRC Laboratory of Molecular Biology"Mechanisms of polarized transport"Host: Thomas Surrey and Adel Al JordAbstract:Asymmetric cell division is the process by which one cell divides into two daughter cells that have different fates. Asymmetric division is the hallmark of stem cells: one daughter cell specialises to perform a specific function in the organism, while the other becomes another stem cell that retains the ability to divide. We are interested in understanding how cell fate determinants segregate asymmetrically during asymmetric division. Specifically, we focus on three...
06/11/202612:00PRBB AuditoriumPRBB-CRG SessionsNicola TernetteUniversity of Dundee"Redefining the HLA-E Immunopeptidome - a new landscape for therapeutic targeting"Host: Eduard SabidóAbstract:HLA-E is a non-classical HLA molecule with limited polymorphism, making it an attractive candidate for broadly applicable immunotherapeutic targeting. Its peptide repertoire, however, remains poorly understood. Using immunopeptidomics, machine-learning assisted prediction, and biochemical validation, we uncover an extended HLA-E immunopeptidome comprising canonical and non-canonical peptides, including cancer-associated ligands shared across individuals and tumour types....