Computational Biology of RNA Processing

Computational Biology of RNA Processing

Bioinformatics and Genomics

Computational Biology of RNA Processing

Group leader
j

Computational Biology of RNA Processing

Group leader
j

1988 Ph.D. in Statistics. Universitat de Barcelona. (Spain).
1988-1993 Postdoctoral researcher at the Molecular Biology Computer Research Resource. Dana Farber Cancer Institute, Harvard University (Division of Biostatistics) BioMolecular Engineering Research Center. Boston University and Theoretical Biology And Biophysics Group (Los Alamos national Laboratory).
Since 1994 Investigator at Institut Municipal d’Investigació Mèdica (IMIM). Barcelona, (Spain).
Since 2001 Associate Professor at the Universitat Pompeu Fabra and coordinator of the Bioinformatics Programme at the Centre de Regulació Genòmica, Barcelona, (Spain).

 Group News

Gene expression is key to understanding differences between individuals and disease susceptibility (07/05/2015)
The Genotype-Tissue Expression (GTEx) project consortia, which includes CRG scientists, have now published their results from their first pilot study in three Science papers.

Trisomy 21: how an extra little chromosome throws the entire genome off balance (16/04/2014)
A study conducted by the University of Geneva (UNIGE), with the collaboration of the Centre for Genomic Regulation (CRG) among many other institutions, shed light on how the extra chromosome 21 upsets the equilibrium of the entire genome.

New advances in the chronic lymphocytic leukaemia genome (26/02/2014)
The Chronic Lymphatic Leukaemia (CLL) Genome Consortium moves closer to the functional study of the genome and its application for improving the treatment of the disease.Their findings are published in the journal Genome Research

Summary

Research in our group focuses on the investigation of the signals involved in gene specification in genomic sequences (promoter elements, splice sites, translation initiation sites, ...). We are interested both in the mechanism of their recognition and processing, and in their evolution. In addition, but related to this basic component of our research, our group is also involved in the development of software for gene prediction and annotation in genomic sequences. Some of our current projects are:

  • Evaluation of Gene Prediction Programmes
  • Gene Prediction software: geneid
  • Genome-Wide Search for Selenoproteins
  • Gene Prediction by Comparative Genomics
  • Splicing
  • Gene Structure Evolution
  • Phylogenetic Reconstruction

See also the Roderic Guigó lab website