CRG Scientific Sessions
21/11/201712:00CHARLES DARWINSystems Biology ProgrammeJohn MarioniThe European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus - UK"Using single-cell RNA-sequencing to provide insight into cell fate"Host: Lehner, BenAbstract:Using single-cell RNA-sequencing to provide insight into cell fate
1. University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK
2. European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK
3. Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton,...
21/11/201716:30R_473.10_AULACell and Developmental Biology ProgrammeCarsten JankeDept. "Genotoxic stress and Cancer". Institut Curie. Orsay, France“Controlling microtubule functions with the tubulin code”Host: Vernos, IsabelleAbstract:The tubulin code is a signalling mechanism that, by altering the identity of single tubulin units of microtubules, controls and fine-tunes microtubule functions in cells. The code is generated by the expression of alternative tubulin genes, called ‘isotypes’, and by the generation of a range of complex posttranslational modifications. Polyglutamylation, polyglycylation and detyrosination are modifications localized at the outer surface of microtubules, and are therefore likely to regulate the...
23/11/201712:00R_473.10_AULAPRBB Computational Genomics SeminarsMarta VivesGenomics and Diase, CRG / Tissue Engineering Facility, CRGPrenatal and postnatal exposure to tobacco smoking and molecular signatures in childrenHost: Garrido Enamorado, Romina
24/11/201711:00R_473.10_AULACell and Developmental Biology ProgrammeGabriele Zaffagnini (candidate seminar)Group Sascha Martens. Max F. Perutz Laboratories. Wien"In vitro reconstitution of p62-mediated autophagy"Host: Boke, ElvanAbstract:Autophagy is a conserved process that delivers bulky cytoplasmic material to the lysosomal compartment for degradation. During autophagy double-membrane organelles, named autophagosomes, are generated de novo and engulf a portion of the cytoplasmic content (cargo). Subsequent fusion of autophagosomes with lysosomes delivers the cargo for degradation. In human cells several autophagic cargos are marked with poly-ubiquitin, and thereby recognized by cargo-receptor proteins. In turn, cargo receptors...
27/11/201712:00MARIE CURIEPRBB-CRG SessionsMichael HottigerDepartment of Molecular Mechanisms of Disease, University of Zurich"Uncovering the functional role of protein ADP-ribosylation on the proeome-wide levelHost: José Yélamos (IMIM)
28/11/201711:00R_473.10_AULACell and Developmental Biology ProgrammeAida Rodríguez (candidate seminar)IRB Barcelona, The Barcelona Institute of Science and Technology; Dept de Bioquímica i Biomedicina Molecular, UB"Linking mitochondria and inflammation: a story of Opa1 deficiency in skeletal muscle"Host: Boke, ElvanAbstract:Opa1 is a mitochondrial GTPase responsible for the fusion of the inner mitochondrial membrane. Skeletal muscle-specific Opa1 ablation causes premature death and reduced growth. Our studies show that Opa1 KO mice present, very early in life, local muscle inflammation characterized by enhanced expression of inflammatory genes via activation of NF-¿B. This primary local effect is followed by necrosis and then...
01/12/201712:00MARIE CURIEPRBB-CRG SessionsGreg GibsonSchool of Biology and Center for Integrative Genomics, Georgia Institute of Technology, Altanta, USA"Canalization and omnigenetics"Host: Jaume Bertranpetit (UPF)
12/12/201711:00R_473.10_AULAGene Regulation,Stem Cells&Cancer Progr.Cornelia H. de Moor, PhDSchool of Pharmacy Building. University Park. Nottingham NG7 2RD. UK“Polyadenylation as a therapeutic target for cancer and inflammatory diseases”Host: Gebauer Hernández, Fátima
28/05/201812:00MARIE CURIEPRBB-CRG SessionsFernando BenavidesLaboratiory Animal Genetic Services, Department of Epigenetics and Molecular Carcinogenesis, MD Anderson Cancer Center, The University of Texas, USA"Inbred mice, similar but different (the devil is in details)Host: Juan Martín-Caballero (PRBB)