Lehner Lab

Lehner LabLehner Lab

Systems Biology

Lehner Lab
Genetic Systems
Group leader

Lehner Lab

Genetic Systems
Group leader

May 2018 - Coordinator, Systems Biology Programme, Centre for Genomic Regulation, Barcelona.
October 2017- Acting Coordinator, Systems Biology Programme, Centre for Genomic Regulation, Barcelona.
May 2014- Senior Group Leader, EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation, Barcelona. 
April 2014-2017 
AXA professor of Risk prediction in age-related diseases
September 2009- ICREA Research Professor
December 2006- Group Leader, EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation, Barcelona.
2004-2006 Postdoctoral Fellow, Fraser Lab, The Wellcome Trust Sanger Institute
2004 PhD University of Cambridge
2000 BA Natural Sciences, University of Cambridge 
We are funded by the European Research Council (ERC),  the EMBL-CRG Program, MINECO, AGAUR, ERASySBio+, ICREA and the AXA Research Fund.
We are located in the Centre for Genomic Regulation which has a beautiful beachfront location in the Barcelona Biomedical Research Park.

Group news

First comprehensive map of amyloid plaque mutations opens new avenues for early detection of Alzheimer’s disease (09/03/2021)
The map will also help researchers better understand the biological mechanisms that control the onset of the disease

Scientists build machine learning-based algorithm to predict which cancer patients benefit from immunotherapy (28/10/2019)
The new technology’s potential is described today in Nature Genetics by researchers at IRB Barcelona, the Centre for Genomic Regulation and Radboud University

Researchers perform thousands of mutations to understand amyotrophic lateral sclerosis (20/09/2019)
Researchers from CRG and IBEC in Barcelona use a technique called high-throughput mutagenesis to study Amyotrophic Lateral Sclerosis (ALS), with unexpected results.

Verónica Llorens and Ben Lehner awarded by the Catalan Society of Biology (24/07/2018)
CRG researchers Verónica Lloréns and Ben Lehner were acknowledged by the Catalan Society of Biology in the 3rd edition of their annual prizes in the categories of Young Investigator and Best Paper respectively.

Big Data analysis identifies new cancer risk genes (10/07/2018)
Researchers at the Centre for Genomic Regulation (CRG) in Barcelona developed a new method to systematically identify genes contributing to heritable cancer risk. Their work, which is published in Nature Communications, is a success story for data sharing and openness in science. Just three researchers identified new cancer genes only using publically available data

Why are genetically identical individuals different? Ask your mum! (29/11/2017)
Does the age of a mother influence the traits and characteristics of her progeny, and how? A team of scientists at the Centre for Genomic Regulation (CRG) in Barcelona have addressed these questions by studying tiny, genetically identical C. elegans worms. Their results have been published today in Nature.

Link between defects in DNA replication and loss of heterochromatin (16/08/2017)
Scientists reveal that a fault in the process that copies DNA during cell division can cause epigenetic changes that may be inherited for up-to five generations. They also identified the cause of these epigenetic changes, which is related to the loss of a molecular mechanism in charge of silencing genes.

Errors made by 'DNA spellchecker’ revealed as important cause of cancer (27/07/2017)
CRG scientists identify important processes that create mutations that cause cancer by studying the genomes of more than 1,000 tumors. Sunlight and alcohol consumption increase the rate at which this happens, resulting in more mutations in the most important parts of our genomes.

Fátima Gebauer and Ben Lehner elected EMBO Members (16/06/2017)
EMBO announced today that 65 outstanding life scientists have been elected to its membership, including CRG group leaders Fatima Gebauer and Ben Lehner. They will be joining a group of more than 1,700 of the best researchers in Europe and around the world.

Environmental ‘memories’ passed on for 14 generations (20/04/2017)
Scientists at the Centre for Genomic Regulation (CRG) in Barcelona and the Josep Carreras Leukaemia Research Institute and The Institute for Health Science Research Germans Trias i Pujol (IGTP) in Badalona, Spain, have discovered that the impact of environmental change can be passed on in the genes of tiny nematode worms for at least 14 generations – the most that has ever been seen in animals.

'Blobs' inside cells could be key to neurodegenerative diseases (16/06/2016)
Liquid droplets of molecules inside cells – similar to the blobs that form when oil and vinegar are mixed – could be behind neurodegenerative conditions such as Parkinson’s and motor neurone disease, according to a study from researchers at the Centre for Genomic Regulation (CRG) in Barcelona, published today in Cell Reports.

Ben Lehner awarded EMBO Gold Medal 2016 (25/05/2016)
Ben Lehner, group leader of the Genetic Systems laboratory at the EMBL-CRG Systems Biology Programme, ICREA research profesor and AXA professor of risk prediction in age-related diseases, has been awarded EMBO Gold Medal 2016.

‘DNA spellchecker’ means that our genes aren’t all equally likely to mutate and cause disease (23/02/2015)
A study that examined 17 million mutations in the genomes of 650 cancer patients concludes that large differences in mutation rates across the human genome are caused by the DNA repair machinery.

Age-related diseases and adversary risk analysis are the two new AXA Research Fund in Spain research chairs (04/04/2014)
The AXA Research Fund has created the permanent AXA Chair in Risk prediction in age-related diseases, given to Ben Lehner, from the Centre for Genomic Regulation (CRG); and...


To what extent is it possible to predict the phenotypic differences amongst individuals from their completely sequenced genomes?  We use model organisms (yeast, worms) and computational analyses to understand when you can, and why you cannot, predict the biology of an individual from their genome sequence.  Individuals are thankfully all different, and our aim is to understand how these differences originate in the interactions between genetic, environmental, life history, parental and stochastic sources of variation.

Other information about the group

Puromycin Selection
Portable Document Format
Puromycin vector sequences
Microsoft Word