Vernos Lab

Vernos LabVernos Lab

Quantitative Cell Biology

Vernos Lab
Microtubule function and cell division
Group leader

Vernos Lab

Microtubule function and cell division
Group leader

1989 PhD, Dpt of Biochemistry, Medical School, Universidad Autónoma de Madrid (Spain)
1989-1992 Postdoctoral work at the University of Cambridge and The Wellcome/CRC Institute, Cambridge, UK.
1992-1996 Postdoctoral work at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
1996-2001 Staff Scientist at EMBL
2001-2005 Team Leader at EMBL
August 2005 ICREA Reseach Professor and Group Leader at the Centre de Regulació Genòmica, Barcelona (Spain).


Cell division enzyme earmarked as potential new cancer therapeutic target (28/11/2022)
The enzyme’s activity was found to be compromised in human cancer cells, paving the way for future research to explore whether cancer exploits the mechanism to grow 

CRG receives Next Generation EU funds for cancer research (24/11/2022)
The projects, led by ICREA Research Professors Luciano Di Croce and Isabelle Vernos, are part a new research programme funded by the Spanish Government and the Generalitat de Catalunya through the Next Generation EU funds.

Chemotargets and the CRG ally to accelerate the development of new treatments (26/10/2021)
The first project under the agreement involves a new target identified by Isabelle Vernos’ group in the CRG’s Cell and Developmental Biology research programme.

A study identifies the key sperm proteins for the development of the embryo (02/07/2018)
Scientists from the Microtubule Function and Cell Division group at the Centre for Genomic Regulation (CRG) and the Eugin Group's basic research laboratory at the Barcelona Scientific Park, have succeeded in identifying 288 proteins found in human sperm and which are key for the formation of the zygote and the subsequent development of the embryo.

CRG and Eugin sign a collaboration agreement on molecular research applied to assisted reproduction (14/03/2018)
The project entails creation of four working groups (Vernos, Boke, Payer, Gabaldón) that will focus their research on gaining insights into the aging of ovules, their sensitivity to the passage of time, and studying whether changes in vaginal microbiota have an impact on assisted reproduction

An experimental technique analyses for the first time the functioning of human sperm before being inseminated into the egg (05/07/2017)
The work of the Centre for Genomic Regulation (CRG) and Eugin Group succeeds in observing the fertilisation capacity of the sperm cell before its insemination in the oocyte.

The sperm tail may determine semen quality (07/07/2016)
Alterations in the sperm tail, which are already present in other species such as the sea urchin or fly, have been identified and may be a determining factor in sperm quality.

Isabelle Vernos awarded the Narcís Monturiol Medal (15/02/2016)
CRG senior group leader and ICREA research professor Isabelle Vernos has been awarded the Narcís Monturiol Medal for scientific and technological merit. 


Research in my lab is directed at understanding the role of the microtubule network in cell organization and function. To address this question we study various microtubule-associated proteins (molecular motors and MAPs) and their regulators (kinases, phosphatases and the small GTPase Ran during M-phase). One major goal is to unravel how the self-organization of cellular components results in the morphogenesis of dynamic molecular machines. At present we are focusing on one example of self-organization: the assembly of the bipolar spindle in mitosis and meiosis.
Our favorite experimental system is the Xenopus egg extract system for studies on cell cycle progression and regulation, microtubule dynamics, spindle assembly and chromosome behaviour (Karsenti and Vernos, 2001). We combine it with the use of human tissue culture cells in which we validate some of the results obtained in egg extract.

Funding Acknowledgements

The project “EL PAPEL DE LA POLYGLUTAMYLACION DE LOS MICROTUBULOS EN LA FIDELIDAD DE LA SEGREGACION DE LOS CROMOSOMAS EN CELULAS NORMALES Y EN CANCER” (PID2021-128064NB-I00) is funded by Agencia Estatal de Investigación (AEI), the Ministerio de Ciencia e Innovación and Fondo Europeo de Desarrollo Regional (FEDER). Official reference number: Project PID2021-128064NB-I00 funded by MCIN/ AEI / 10.13039/501100011033 / FEDER, UE