Gene Regulation, Stem Cells and Cancer
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1999 PhD Institut de Biologia Fonamental, Universitat Autònoma de Barcelona (Spain)
1999-2003 Postdoctoral work at the Rockefeller University, New York (NY, USA).
2003-2006 Assistant Adjunct Professor, UCSF, San Francisco (CA, USA)
2006-2011 Group Leader at the CIPF, Valencia (Spain)
2012-today Group Leader at the CNAG-CRG, Barcelona (Spain)
2012-today Affiliated Group Leader to the CRG, Barcelona (Spain)
2013-today ICREA Research Professor
Our group web site: http://www.marciuslab.org
When a chemical tag makes the difference in cell fate and gene expression (18/09/2018)
Scientists at the Centre for Genomic Regulation in Barcelona, Spain, have uncovered the role of special chemical ‘tags’ in controlling vital genes involved in early mammalian development, publishing their findings in the journal Nature Genetics on 17thSeptember.
Deciphering the role of cohesin in the 3D organisation of the genome allows for a better understanding of tumour cells (04/06/2018)
A study led by scientists from the Centro Nacional de Análisis Genómico of the Centre for Genomic Regulation (CNAG-CRG) and the Spanish National Cancer Research Centre (CNIO), deciphers the role of two variants of cohesin –a protein complex essential for cell viability– in the 3D organisation of the genome.
Genome architecture’s surprising role in cell fate decisions (15/01/2018)
New study led by researchers at the Centre for Genomic Regulation (CRG) in Barcelona, Spain, shows unexpected and crucial role of genome architecture in determining cell fate.
We are interested in the molecular mechanisms that regulate cell fate. To study such mechanisms, we employ the laws of physics and the rules of evolution to develop and apply computational methods for predicting the 3D structures of macromolecules and their complexes. Our current lines of research are:
Open Source drug discovery projects for tropical diseases
We develop methods for comparative docking of small chemical compounds and their target proteins. Such methods have already been applied to identify drug targets in ten genomes that cause tropical diseases. This work is part of the Tropical Disease Initiative and is funded by the Spanish Ministerio de Ciencia e Innovación.
RNA structure prediction
The recent interest in RNA, specially non-coding RNA molecules, has prompted us to develop a series of tools for the alignment of RNA structures and the prediction of their functions. This work has been funded by a Marie Curie action and a Generalitat Valenciana research grant.
Structure determination of genomes
More recently, we have engaged collaboration with experimentalists to study the 3D organization of the chromatin. Such work is resulting in the first ever structures of genomic domains and entire genomes.
ERC Synergy Project - Dynamics of Genome Architecture in Stable and Transient Changes in Gene Expression
Chromosomes and genes are non-randomly positioned in the cell nucleus and the vision of a dynamic and complex organization of the nucleus is replacing the classical view of genomes as linear sequences. (+more info)