Gene Regulation, Stem Cells and Cancer

Gene Regulation, Stem Cells and Cancer

Gene Regulation, Stem Cells and Cancer

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Coordinator: Juan Valcárcel

The interests of the program span from mechanisms of gene expression and epigenetic regulation to the molecular basis of cellular decisions involved in tissue homeostasis and cancer.

Mechanistic studies of gene regulation include the organization and evolution of the regulatory genome (Dr. Guillaume Filion), chromatin structure and transcriptional regulation mediated by steroid hormones (Dr. Miguel Beato), epigenetic mechanisms in leukemia and stem cells (Dr. Luciano Di Croce), regulation of alternative splicing (Dr. Juan Valcárcel) and cytoplasmic polyadenylation and mRNA translation (Dr. Fátima Gebauer), gene function (Dr. Susana de la Luna) and epigenetic reprogramming in embryogenesis and the germline (Dr. Bernhard Payer). Stem cell studies include differentiation and transdifferentiation in the hematopoietic system (Dr. Thomas Graf), and somatic cell reprogramming and tissue regeneration (Dr. Maria Pia Cosma) .

SOCIAL ACTIVITIES: The program’s retreat, November 2016 (pictures)

SOCIAL ACTIVITIES: The program’s retreat, October 2013 (pictures)


Juan Valcárcel Juárez
Thomas Graf
Miguel Beato del Rosal
Luciano Di Croce
Maria Pia Cosma
Fátima Gebauer
Susana De la Luna Gargantilla
Guillaume Filion
Bernhard Payer
Eva Maria Novoa Pardo
Sara Sdelci
Renée Beekman


Marc A. Marti-Renom
Manuel Irimia


Integrated in a senior research group, Staff Scientists support the research of the group, while having a degree of scientific independence to lead their own research line (i.e. co‐mentoring of PhD students, being senior authors in publications and applying for grants). As Faculty Members, Staff Scientists are evaluated every 4 years by an external committee composed of SAB and ad‐hoc members in the framework of the Programme’s evaluation.

Sergio Aranda Aragón
Sophie Bonnal