Role of TFIIIC and Pol-III transcription in genome organization and gene regulation
TFIIICcan act as an insulator that participates in 3D genome organization. We found an intimate relationship between TFIIIC and PR in breast cancer cells. Upon serum starvation TFIIIC is relocated from Pol-III genes to repetitive elements near Po-II gene, and upon hormone exposure PR binds nearby and activates transcription. We hypothesized that TFIIIC might be a sensor of growth signal that contributes to genomic rearrangements needed for rapid response to nutrient changes and we will explore whether its contribution to the cancer phenotype.