Gene Regulation,Stem Cells Cancer description

Co-Coordinators: Fátima Gebauer and Luciano Di Croce

The Genome Biology program focuses on investigating the mechanisms that lead to expression of our genome during homeostasis, cell reprogramming, and disease. We use quantitative ‘omics’ technologies, mathematical modeling, cellular biology and mouse genetics to understand chromatin organization, transcription, splicing, mRNA translation, signaling and RNA modification. Mechanisms of gene expression control are studied in the context of a variety of diseases including cancer (leukemia, lymphoma, pancreatic and lung adenocarcinomas, gliomas, melanoma, breast cancer), Down syndrome and fertility disorders.

Transcriptional regulation groups study effects of dosage imbalance of chromosome 21 (Dr. Susana de la Luna), epigenetic mechanisms in cancer and stem cells (Dr. Luciano Di Croce), single cell epigenomics in lymphomas (Dr. Renee Beekman), and epigenetic regulation of cancer metabolism (Dr. Sara Sdelci). RNA biology groups study the identification and control of RNA modifications (Dr. Eva Novoa), the regulation of alternative splicing (Dr. Juan Valcárcel) and the regulation of mRNA translation (Dr. Fátima Gebauer). Cell reprogramming studies include differentiation and trans-differentiation in the hematopoietic system (Dr. Thomas Graf), and epigenetic reprogramming in embryogenesis and the germline (Dr. Bernhard Payer).

SOCIAL ACTIVITIES: The program’s retreat, November 2019 (pictures and video)

SOCIAL ACTIVITIES: The program’s retreat, November 2016 (pictures)

SOCIAL ACTIVITIES: The program’s retreat, October 2013 (pictures)