Guigó Lab

Guigó LabGuigó Lab

Computational Biology and Health Genomics

Guigó Lab
Computational Biology of RNA Processing
Group leader

Guigó Lab

Computational Biology of RNA Processing
Group leader

1988 Ph.D. in Statistics. Universitat de Barcelona. (Spain).
1988-1993 Postdoctoral researcher at the Molecular Biology Computer Research Resource. Dana Farber Cancer Institute, Harvard University (Division of Biostatistics) BioMolecular Engineering Research Center. Boston University and Theoretical Biology and Biophysics Group (Los Alamos National Laboratory).
1994-2010 Investigator at Institut Municipal d’Investigació Mèdica (IMIM). Barcelona, (Spain).
2001-2005 Associate Professor at the Universitat Pompeu Fabra. Barcelona, (Spain).
2001-2022 Coordinator of the Bioinformatics Programme at the Centre de Regulació Genòmica, Barcelona, (Spain).
Since 2005 Professor at the Universitat Pompeu Fabra. Barcelona, (Spain).

See also the Roderic Guigó lab website


Epigenome mapped in detail across human body (30/03/2023)
An international research collaboration has addressed this challenge by cataloguing the human epigenome in unprecedented detail, charting the whole collection of epigenomic marks in more than 25 different types of tissues across the human body.

‘Space bacteria’ set to land in Barcelona (16/03/2023)
A new collaboration between the CRG and yuri GmbH, a commercial space biotechnology company in Germany, will bring together researchers to harness the power of microgravity conditions in space and study its impact on human health, cells, and plant biology.

Seasonal and circadian genetic variation charted across the human body (13/02/2023)
A research team at the CRG have published research in PLOS Biology which details how the circadian and circannual cycles influence humans at the molecular level by measuring changes to the activity of genes inside cells across different types of tissues. 

CRG joins international efforts to protect human health from effects of harmful chemicals (11/03/2021)
Roderic Guigó will lead the CRG's contributions to the international consortium

CRG signs biodiversity genomic sequencing agreement with Andorra (01/03/2021)
This is the first time the country has been involved in a project of this magnitude

Small but ubiquitous sex differences in gene expression in human tissues linked to body fat, cancer, and birth weight (10/09/2020)
A study published today in Science reveals that biological sex has a small but ubiquitous influence on gene expression in almost every type of human tissue.

Human body mostly composed of just five major groups of cell (30/07/2020)
Scientists around the world have today published the results of the third phase of the Encyclopedia of DNA Elements (ENCODE) in Nature. 

A study describes the dynamics of chromatin during organ and tissue regeneration (04/12/2018)
Researchers discover the genes and regulatory elements of their expression that are required during the process of tissue and organ regeneration in the fruit fly. The article appears highlighted in the cover of the Genome Research journal in December.

Roderic Guigó and Toni Gabaldón among the most highly cited researchers in the world (30/11/2018)
Two CRG group leaders are among the most highly cited researchers in the world, according to the list established by Clarivate Analytics.

Roderic Guigó receives the National Research Award (19/10/2018)
Roderic Guigó, coordinator of the CRG Bioinformatics and Genomics Programme, received the National Research Award. The award ceremony took place at the National Theatre of Catalonia in Barcelona on 15th October and it was chaired by the President of the Catalan Government, Mr. Quim Torra. 

Gene expression patterns may help determine time of death (13/02/2018)
International team of scientists led by CRG programme coordinator Roderic Guigó shows that changes in gene expression in different tissues can be used to predict the time of death of individuals.

National Research Award 2017 to Roderic Guigó (27/12/2017)
Roderic Guigó, coordinator of the CRG Bioinformatics and Genomics Programme, honored with the highest recognition for research excellence in Catalonia.

A new method accelerates the mapping of genes in the “Dark Matter” of our DNA (06/11/2017)
Scientists at the Centre for Genomic Regulation (CRG) in Barcelona, have developed a new method, which improved the most important catalogue of genes -GENCODE-, including characterization of new genes in the DNA “Dark Matter”.

Genome Editing: Pressing the «Delete» Button on DNA (02/03/2017)
Until recently, genomics was a «read-only» science. But scientists led by Rory Johnson at the University of Bern and the Centre for Genomic Regulation in Barcelona, have now developed a tool for quick and easy deletion of DNA in living cells. This software will boost efforts to understand the vast regions of non-coding DNA, or «Dark Matter», in our DNA and may lead to discovery of new disease-causing genes and potential new drugs.

Spanish scientists sequence the genome of the Iberian lynx, the most endangered felid (14/12/2016)
Genomic analysis of the Iberian lynx confirms that it is one of the species with the least genetic diversity among individuals, which means that it has little margin for adaptation.

The Blueprint project celebrates major manuscript release (18/11/2016)
BLUEPRINT scientists, including researchers at the Centre for Genomic Regulation, release a collection of 25 publications in Cell, Cell Press-associated and other high-impact journals. These are part of a package of 41 publications by the International Human Epigenome Consortium (IHEC) of which BLUEPRINT is a member.

'Blueprint' study of epigenetics of blood cells will serve biology and medicine (07/09/2016)
Researchers from the EU-funded BLUEPRINT project join their international colleagues this week at the 2016 International Human Epigenome Consortium (IHEC) conference in Brussels to report the latest results in understanding blood cell development and blood disease.

CRG researchers contribute to the sequencing of the Turbot genome (09/03/2016)
The first vertebrate to be genetically sequenced in Spain, the Turbot (Scophthalmus maximus), has a much more refined visual system than other fish as it has evolved to adapt to the shortage of light of the seabed. In addition, the fat in its cell membranes are far higher than in other species to withstand the low water temperatures in its habitat.

The mesoamerican bean genome decoded (25/02/2016)
An Ibero-American team of scientists decoded the Mesoamerican variety of the bean genome coinciding with the celebration of the International Year of Pulses, as designated by the United Nations.

Funding acknowledgements

The "VEIS-Valorisation of EGA for Industry and Society" (VEIS-001-P-001647) project is cofunded by the European Regional Development Fund of the European Union in the framework of the ERDF Operative Program of Catalonia 2014-2020, with a grant of 1,951,429.38 EUR, with the support of the Department of Research and Universities of the Government of Catalonia.

    The project “MAPAS GENETICOS Y EPIGENETICOS A LO LARGO DE LA FILOGENIA EUCARIOTA” (PID2021-128956NB-I00) is funded by Agencia Estatal de Investigación (AEI), the Ministerio de Ciencia e Innovación and Fondo Europeo de Desarrollo Regional (FEDER). Project PID2021-128956NB-I00 funded by MCIN/ AEI / 10.13039/501100011033 / FEDER, UE

    The 'IMPaCT' project, with official reference IMP/00019, has been granted by the ISCIII, under the Infraestructura de Medicina de Precisión asociada a la Ciencia y Tecnología (IMPaCT) - Ciencia de Datos Call, the Spanish Ministry of Science and Innovation, and cofunded with ERDF Funds from the European Union.
    Period: 01/01/2021 to 31/12/2023
    Ref.: IMP/00019

    The project 'Omplint el buit del mercat del single cell', granted under the call from 'Industria del Coneixement (Llavor i Producte), has received funding from the Department of Research and Universities, of the Government of Catalonia
    Period: 19/10/2022 to 18/04/2024

    The project “GENCODE: comprehensive reference genome annotation for human and mouse” has been granted by the NATIONAL INSTITUTE OF HEALTH – NIH with reference 2U24HG007234-09 .
    Period: 14/09/2021 to 30/06/2025
    Ref.: 2U24HG007234-09

    The project 'Long-TREC: The Long-Reads Transcriptomics European Consortium. The next generation transcriptome biology revealed by single molecule sequencing technologies' has received funding from the European Union's HORIZON-MSCA-2021-DN-01-01 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 101072892.
    Period: 01/10/2022 to 30/09/2026
    Ref.: Marie Sklodowska-Curie grant agreement No 101072892


    The Flux Simulator aims at modeling RNA-Seq experiments in silico: sequencing reads are produced from a reference genome according annotated transcripts.

    Contact person:

    The GEM (GEnome Multi-tool) Library is a set of very optimized tools for indexing/querying huge genomes/files.


    A set of very optimized tools for indexing/querying huge genomes/files. Provided so far: a very fast exact mapper, and an unconstrained split-mapper

    Contact person:

    The resource described, the U12 Intron Database (U12DB), aims to catalog the U12 introns of completely sequenced eukaryotic genomes and associate orthologous introns with each other.

    Gene Analysis

    U12-type introns are spliced by the U12-dependent spliceosome and are present in the genomes of many higher eukaryotic lineages including plants, chordates and some invertebrates. Investigations into the evolution and mechanism of U12-depending splicing would be facilitated by access to a catalog of such introns. However, due to their relatively recent discovery and a systematic bias against recognition of non-canonical splice sites in general, the introns defined by U12-type splice sites are under-represented in genome annotations. Such under-representation compounds the already difficult problem of determining gene structures. It also impedes attempts to study these introns genome-wide or phylum-wide. The resource described here, the U12 Intron Database (U12DB), aims to catalog the U12 introns of completely sequenced eukaryotic genomes and associate orthologous introns with each other.