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CRG Scientific Sessions

CRG Scientific Sessions

20/01/202012:00MARIE CURIEPRBB-CRG SessionsCédric BlanpainWELBIO, Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, BE"to be determined"Host: Antoni Celià Terrassa (IMIM)

24/01/202010:00MARIE CURIEBioinformatics and Genomics ProgrammeDanny IncarnatoAssistant Professor. Groningen Biomolecular Sciences and Biotechnology Institute (GBB) / Group Leader. Buchmann Institute for Molecular Life Sciences,Dissecting the in vivo RNA structuromeHost: Tartaglia, Gian Gaetano

31/01/202012:00MARIE CURIEPRBB-CRG SessionsAndrew BrownUniversity of Dundee, Scotland, UK"Finding and exploiting causal regulatory variants in the GTEx data"Host: Roderic GuigóAbstract:Fine-mapping of cis-regulatory variants can enhance our understanding of the mechanisms of gene expression and the links between expression and disease. The latest GTEx data provided RNA-seq and WGS from 838 individuals across 49 tissues. We applied 3 published fine-mapping methods to these data: CaVEMaN, CAVIAR and dap-g. We find 68,948 high confidence causal variants (P>0.8), with a median number of 6 variants in a 95% credible set. Fine-mapping approaches can also...

14/02/202012:00CHARLES DARWINGene Regulation,Stem Cells&Cancer Progr.José SilvaWellcome - MRC Cambridge Stem Cell Institute, Cambridge, UK"Deciphering Induced Pluripotency"Host: Payer, Bernhard

20/02/202012:00MARIE CURIESystems Biology ProgrammeLea StaritaDepartment of Genome Sciences, Brotman Baty Institute, University of Washington“Understanding the functional effects of coding variation, at scale”Host: Lehner, BenAbstract:Interpreting the effects of genetic variation is the central challenge for the progress and prospects of precision medicine. Variant-effect prediction algorithms can classify any possible genetic variation but despite substantial efforts, they do not have the accuracy to support their use in a clinical setting. On the other hand, experimentally testing the effect of each individual variant on protein function or gene expression yields high-quality information, but is low-throughput. To resolve this, we...

21/02/202010:00R_473.10_AULASystems Biology ProgrammeJolanda van LeeuwenUniversity of Lausanne, Lausanne"Systematic analysis of genetic suppression interactions"Host: Lehner, BenAbstract:Recent genome sequencing efforts have identified people that are healthy despite carrying mutations that have been directly associated with severe early-onset Mendelian diseases. These resilient individuals may carry secondary mutations elsewhere in the genome that can compensate for the deleterious effect of the disease-associated mutation, a phenomenon referred to as genetic suppression. Identification of the protective mutations could highlight strategies for therapeutic intervention, but we currently lack the expertise to identify the suppressor...

21/02/202012:00MARIE CURIEPRBB-CRG SessionsSimon AlbertiMax Planck Institute of Molecular Cell Biology and Genetics (MPI-CBd), Dresden, Germany"Phase separation as an organizing principle in biology"Host: Sebastian MaurerAbstract:We aim to understand how cells change their internal organization upon environmental perturbations, stress and aging. Stressed cells undergo controlled changes on many levels to alter their physiology and metabolism. Many of these changes appear to directly result from alterations in the organization of the cytoplasm. Indeed, recent work from my lab shows that stressed cells form many membraneless...

28/02/202012:00MARIE CURIEPRBB-CRG SessionsMichael KieblerBioMedizinisches Centrum, Lehrstuhl Zellbiologie (Anatomie III), LMU, Martinsried, Germany"to be determined"Host: Fátima Gebauer and Sebastian Maurer

06/03/202012:00MARIE CURIEPRBB-CRG SessionsIgor UlitskyWeizmann Institute of Science, Rehovot, IL"Functions and modes of action of long noncoding RNAs in mammalian cells"Host: Jorge FerrerAbstract:We are interested in understanding the codes that drive the functions of long noncoding RNAs (lncRNAs) in mammalian cells. It is now well appreciated that the human genome encodes tens of thousands of distinct lncRNA transcripts, and an increasing number are implicated as regulators in critical pathways in health and disease. The mechanisms underlying their activity, to what extent these rely on specific sequences or structures, and how they are...

06/03/202012:00MARIE CURIEPRBB-CRG SessionsHeiko LickertHelmholtz Zentrum München GmbH, Institute of Diabetes & Regeneration Research, Helmholtz Diabetes Centre, Germany"to be determined"Host: Jorge Ferrer

13/03/202012:00MARIE CURIEPRBB-CRG SessionsRab PrinjhaVP, Head of Epinova Epigenetics DPU, VP Head of Epigenetics DPU (Immuno- and Cancer-Epigenetics), GlaxoSmithKline, UK"Drugging Transcription: Progress and Potential for Treating Human Diseases"Host: Luciano Di Croce

20/03/202012:00MARIE CURIEPRBB-CRG SessionsErin ShcumanMax Planck Institute for Brain Research, Frankfurt, DE"to be determined"Host: Juan Valcárcel

27/03/202012:00MARIE CURIEPRBB-CRG SessionsJames HackettEMBL Rome, IT"to be determined"Host: CRG PhD Students

03/04/202012:00MARIE CURIEPRBB-CRG SessionsIñigo MartincorenaWellcome Sanger Institute, Hinxton, UK"to be determined"Host: CRG PhD Students

16/10/202012:00MARIE CURIEPRBB-CRG SessionsAnne Ferguson-SmithUniversity of Cambridge. Department of Genetics"to be determined"Host: Bernhard PayerAbstract:Gene expression is not only regulated at the level of transcription, but also at many post-transcriptional steps. Various classes of non-coding RNAs have been identified that affect gene expression including microRNAs, lncRNAs or circular RNAs, which are generated by alternative splicing and can function as sponges for miRNAs or RNA-binding proteins. RNAs do not function as sole RNA molecules but are instead incorporated into RNA-protein complexes, in which at least one RNA-binding protein (RBP)...