CRG Scientific Sessions
16/09/202512:00R_473.10_AULASystems Biology ProgrammeNoelia FerruzFerruz Lab“Controllable protein design with language models”Host: Blanc Medrano, Esther
16/09/202516:00R_473.10_AULAGene Regulation,Stem Cells&Cancer Progr.Júlia Portell I De MontserratIMBA ViennaTarget binding triggers PIWI* complex assembly for transposon silencingHost: Tagliaferro, Barbara
18/09/202511:00R_473.10_AULAGene Regulation,Stem Cells&Cancer Progr.Professor Mark Dawson FAA; FAHMSMBBS; BMedSci; FRACP; FRCPA; PhD Professor, Sir Peter MacCallum Department of Oncology- Transcription and clonality: The foundation for understanding epigenetic influences on health and diseaseHost: Tagliaferro, Barbara
23/09/202514:00R_473.10_AULACRGPedro González (Co-Founder, CSO); Toni Gabaldon (Co-Founder, Scientific Advisor); Jordi Navarro (CEO)microomicsIndustry SeminarHost: Potter, Michael
26/09/202511:00R_473.10_AULACell and Developmental Biology ProgrammeRoop MallikIndian Institute of Technology BombayThe Dynein Motor and it's Catch Bond in Intracellular TransportHost: Benito Mestres, MartaAbstract:Molecular Motors generate Force to transport many kinds of vesicles in bidirectional (i.e. back-and-forth) manner along microtubules inside cells. We have used Optical Tweezers to measure these forces and inferred that the transport of Endosomes involves a team of seven to ten Dynein motors that engages in Tug-of-War against one or two Kinesin motors. Given the larger number of dyneins and the known ON/OFF rates for motors, it appears that endosome motion should be dominated by Dynein. So, how does Kinesin ever get a chance...
26/09/202512:00MARIE CURIEPRBB-CRG SessionsElinor KarlssonBroad Institute of MIT and Harvard & UMass Chan Medical School"Discovering the Genomic Basis of Exceptional Traits Across Mammals"Host: Donate WeghornAbstract:The Zoonomia Project, one of the largest comparative genomics initiatives ever undertaken, compared 240 mammalian species spanning over 100 million years of evolutionary history. This work revealed that at least 11% of the human genome is evolutionarily constrained, and that constrained bases are more enriched for variants that explain common disease heritability than any other functional annotation. Yet nearly half of the most highly...
03/10/202512:00MARIE CURIEPRBB-CRG SessionsChristina LeslieMemorial Sloan Kettering Cancer Center"TBC"Host: Fanny Mollandin & Jorge Ferrer
17/10/202512:00MARIE CURIEPRBB-CRG SessionsMichael HillerLOEWE Centre for Translational Biodiversity GenomicsLinking phenotypic differences between species to differences in their genomesHost: Manuel IrimiaAbstract:In the first part of the talk, I will present TOGA (Tool to infer Orthologs from Genome Alignments) version 2.0, the completely reimplemented successor to the original method that simultaneously annotates coding genes and infers orthologs. TOGA 2.0 provides several new features, among them deep learning-based splice site predictions, which enable the method to cope with exon boundary shifts and evolutionary exon-intron structure changes.
In the...
31/10/202512:00MARIE CURIEPRBB-CRG SessionsKristen VerheyUniversity of Michigan Medical School"TBC"Host: Thomas Surrey
14/11/202512:00MARIE CURIEPRBB-CRG SessionsAlexander van OudenaardenHubrecht Institute"TBC"Host: Renee Beekman