CRG Scientific Sessions
29/10/202615:00R_473.10_AULACBHG Program SeminarShimin ShuaiSchool of Medicine, SUSTECH Shenzhen, Guangdong, ChinaComputational Omics to Decode Disease Ecosystems: From RNA Processing to Tumor EcotypesHost: Rodríguez Martín, BernardoAbstract:Disease is a dynamic ecosystem, and omics data capture it at unprecedented scale. Decoding it requires computational methods that are both rigorous and anchored in experiments. I will present three studies that move from the molecular to the ecosystem scale. Within cells, Perturb-Seq analysis identified global regulators of RNA processing. Between hosts and microbes, benchmarking TCGA tumor microbiota showed that many associations are spurious; a confidence-graded framework (MOMAC2) pinpointed...
06/11/202612:00PRBB AuditoriumPRBB-CRG SessionsNicola TernetteUniversity of Dundee"Redefining the HLA-E Immunopeptidome - a new landscape for therapeutic targeting"Host: Eduard SabidóAbstract:HLA-E is a non-classical HLA molecule with limited polymorphism, making it an attractive candidate for broadly applicable immunotherapeutic targeting. Its peptide repertoire, however, remains poorly understood. Using immunopeptidomics, machine-learning assisted prediction, and biochemical validation, we uncover an extended HLA-E immunopeptidome comprising canonical and non-canonical peptides, including cancer-associated ligands shared across individuals and tumour types....
04/02/202715:00R_473.10_AULAGene Regulation,Stem Cells&Cancer Progr.Nicholas KatsanisTBCOne Plus One Equals ZeroHost: Tagliaferro, Barbara