Most of the structures and function of globular domains from the proteome are yet unknown. In order to get some information about the biological role of these domains, the development of a methodology for the modelling, prediction and localization of putative partners is of crucial importance since it can be of general applicability for any domain involved in protein-protein interactions.
ADAN is a database of putative ligands for the most well-known modular protein-protein interaction domains like SH3, PDZ, etc. Many of these domains have a large number of homologues of which only a small fraction has been crystallized and only limited number of ligands is known. Based on the known structures, the ADAN project creates full atomic models of unknown protein-ligand structures using the FoldX algorithm and predicts new putative binders. A querying function allows the user to input a polypeptide sequence and retrieve the putative binding segments for a particular domain.
ADAN results from the collaboration between the group of Luis Serrano, currently at the CRG in Barcelona and Gregorio Fernández, researcher from the Cellular and Molecular Biology Institute of the Miguel Hernández University in Elche, Alicante.
The annual RECOMB Comparative Genomics Satellite Conference (RECOMB-CG) brings together leading researchers in the mathematical, computational and life sciences to discuss cutting edge research in comparative genomics, with an emphasis on computational approaches and the analysis of novel experimental results. The program will include keynote talks, contributed talks, and a poster session.
The workshop is an international venue aimed at managers and staff of research core facilities (microscopy, proteomics, flow cytometry, genomics, sequencing, histology, animal house, etc.), to discuss the best ways to manage and run facilities for science, to solve technical, scientific, and management problems, and to establish collaborations by networking with peers. Managers, core staff, and industrial partners are all invited to participate.
Barcelona celebra un any més la Setmana Mundial del Cervell (del 13 al 19 de març de 2017), que enguany arriba a la seva 22a edició. De nou, els científics dels centres d'investigació surten al carrer per donar a conèixer els darrers avenços en el camp de les neurociències. El programa adreçarà activitats per al públic general, estudiants, pacients i professionals de mitjans de comunicació en diferents formats: xerrades, concerts, tallers i activitats escolars.
Programa
Evolutionary theory forms the basis for our understanding of the natural world. The development, behaviour and physiology of our own species has been shaped by million of years of evolution.
The CRG Gender Balance Committee together with the PRBB is pleased to invite you to the annual celebration of the International Women’s Day on the 8th of March. This year we would like to welcome you to 1h30 event that will include the short film session, core subject discussion and sandwiches!
We would like to invite you to our thematic happy hour – hot chocolate served with fartons (long sponge cakes) & carnival party where you can mingle with people from other programs and administration.
Come and join us for a hot drink and have a chat with your CRG-CNAG colleagues. It will be a great occasion to network with your coworkers, whilst enjoying a wonderful time together & amazing views to the sea.
Whole-cell models are promising tools for predicting phenotype from genotype by accounting for every individual gene and cell function. Whole-cell modeling has the potential to enable rational bioengineering and precision medicine. However, significant work remains to develop fully complete and accurate whole-cell models. The goal of the 2017 Whole-Cell Modeling Summer School is to provide young investigators cutting-edge training in large-scale dynamical modeling and model integration.
