CBHG Program Seminar Shimin Shuai

29/10/202615:00R_473.10_AULACBHG Program SeminarShimin ShuaiSchool of Medicine, SUSTECH Shenzhen, Guangdong, ChinaComputational Omics to Decode Disease Ecosystems: From RNA Processing to Tumor EcotypesHost: Rodríguez Martín, BernardoAbstract:Disease is a dynamic ecosystem, and omics data capture it at unprecedented scale. Decoding it requires computational methods that are both rigorous and anchored in experiments. I will present three studies that move from the molecular to the ecosystem scale. Within cells, Perturb-Seq analysis identified global regulators of RNA processing. Between hosts and microbes, benchmarking TCGA tumor microbiota showed that many associations are spurious; a confidence-graded framework (MOMAC2) pinpointed reliable signals, including Streptococcus anginosus, which promotes oral cancer cell growth. Across the tumor tissue, multi-omics profiling of oral carcinogenesis defined two ecotypes, and targeting TNFRSF12A overcame immune exclusion and sensitized tumors to anti-PD-1 therapy. Together, these studies show how computational omics, paired with functional validation, can reveal the logic of disease ecosystems and guide intervention.