CBHG Program Seminar Ji Won Oh

22/10/202610:00R_473.10_AULACBHG Program SeminarJi Won OhDepartment of Anatomy, Yonsei University College of MedicinetbcHost: Velten, LarsAbstract:How the first cells of the human embryo give rise to the adult body remains one of the fundamental open questions in biology, because human development cannot be observed or traced prospectively. Every cell division, however, leaves a record: somatic mutations acquired in the earliest blastomeres are inherited by all of their descendants and persist throughout life. Post-mortem tissues collected across the body therefore preserve a retrospective record of early human development. Using post-mortem tissues sampled across the body from multiple individuals, we combined clonal expansion of single cells with deep, multi-site targeted sequencing to reconstruct early lineage trees at high resolution. In this talk, I will discuss how early blastomeres contribute unequally to different organs, how their descendants are distributed across the body, and what these patterns reveal about the organization of early human development. I will also address the implications of these findings for interpreting mosaic disorders and for designing tissue sampling in clinical diagnosis.