PRBB-CRG Sessions Martin Eilers

12/06/202612:00MARIE CURIEPRBB-CRG SessionsMartin EilersBiozentrum Universität Würzburg"Role of non-canonical functions of MYC in oncogenesis"Host: Thomas GrafAbstract:MYC proteins are central oncogenes that contribute to the development of the majority of human cancers. They are classically viewed as DNA-bound transcription factors that regulate gene expression by forming heterodimers with the partner protein MAX. However, this canonical model does not readily explain several key oncogenic functions of MYC, such as its ability to promote immune evasion. In my talk, I will discuss the mechanisms by which pancreatic carcinoma evades immune destruction as a paradigm of a MYC dependent cancer. I will highlight emerging non canonical functions of MYC, including its capacity to bind nascent RNA and show how these activities drive immune evasion. Finally, I will briefly outline how these insights reshape strategies to therapeutically target MYC in cancer