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Do liquid crystal-like phases of proteins organize membrane compartments?

Principal Investigator/s: 

We know that intracellular organisation into organelles relies on the formation of lipid bilayers and allows cells to compartmentalise different processes. However, the existence of non-membrane bound compartments, such as nucleoli, raises the question of how cells keep such regions distinct and prevent their context from mixing with the surroundings. The EU-funded LiquOrg project will challenge the concept that membrane-less organelles are formed by liquid-liquid phase separation and proposes a liquid crystal hypothesis where surface proteins organise into multiple layers which surround and enclose their membranes. Researchers will use the Golgi apparatus and the golgin proteins as proof of concept.

01/09/2021 31/08/2027
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