CRG Scientific Sessions
23/10/202611:00R_473.10_AULASystems Biology ProgrammeYuliaxis RamayoInstitute of Agrifood Research and Technology"Exploring Gut-BrainHost: Blanc Medrano, Esther
23/10/202612:00MARIE CURIEPRBB-CRG SessionsElisa OricchioEPFL"Chromatin Remodeling as a Mechanism of Cancer Evolution"Host: Renée BeekmanAbstract:Cancer is a disease that adapts and evolves in response to various growth conditions and environmental signals through genetic, epigenetic, and transcriptional modifications. The genetic evolution of a tumor occurs as a result of the gradual accumulation of genomic alterations, such as mutations and chromosomal abnormalities. However, tumors can continue to progress and develop resistance to treatments even without acquiring new genetic lesions, underscoring the importance of non-genetic mechanisms in tumor evolution. In my...
29/10/202615:00R_473.10_AULACBHG Program SeminarShimin ShuaiSchool of Medicine, SUSTECH Shenzhen, Guangdong, ChinaComputational Omics to Decode Disease Ecosystems: From RNA Processing to Tumor EcotypesHost: Rodríguez Martín, BernardoAbstract:Disease is a dynamic ecosystem, and omics data capture it at unprecedented scale. Decoding it requires computational methods that are both rigorous and anchored in experiments. I will present three studies that move from the molecular to the ecosystem scale. Within cells, Perturb-Seq analysis identified global regulators of RNA processing. Between hosts and microbes, benchmarking TCGA tumor microbiota showed that many associations are spurious; a confidence-graded framework (MOMAC2) pinpointed...
30/10/202612:00MARIE CURIEPRBB-CRG SessionsEmmanuel DeriveryMRC Laboratory of Molecular Biology"Mechanisms of polarized transport"Host: Thomas Surrey & Adel Al JordAbstract:Asymmetric cell division is the process by which one cell divides into two daughter cells that have different fates. Asymmetric division is the hallmark of stem cells: one daughter cell specialises to perform a specific function in the organism, while the other becomes another stem cell that retains the ability to divide. We are interested in understanding how cell fate determinants segregate asymmetrically during asymmetric division. Specifically, we focus on...
06/11/202612:00PRBB AuditoriumPRBB-CRG SessionsNicola TernetteUniversity of Dundee"Redefining the HLA-E Immunopeptidome - a new landscape for therapeutic targeting"Host: Eduard SabidóAbstract:HLA-E is a non-classical HLA molecule with limited polymorphism, making it an attractive candidate for broadly applicable immunotherapeutic targeting. Its peptide repertoire, however, remains poorly understood. Using immunopeptidomics, machine-learning assisted prediction, and biochemical validation, we uncover an extended HLA-E immunopeptidome comprising canonical and non-canonical peptides, including cancer-associated ligands shared across individuals and tumour types....
04/02/202715:00R_473.10_AULAGene Regulation,Stem Cells&Cancer Progr.Nicholas KatsanisTBCOne Plus One Equals ZeroHost: Tagliaferro, Barbara