Velten Lab

Velten LabVelten Lab

Bioinformatics and Genomics

Velten Lab
Single Cell Genomics of Tissue Regeneration
Group leader

Velten Lab

Single Cell Genomics of Tissue Regeneration
Group leader

2020-Today Group Leader at the Centre for Genomic Regulation (CRG), Barcelona, Spain
2016-2019 Research Staff Scientist, European Molecular Biology Laboratory, Heidelberg (Germany)
2012-2016 Ph.D. in Genomics, European Molecular Biology Laboratory, Heidelberg (Germany)
2012 M.Sc. in Cancer Biology, German Cancer Research Center, Heidelberg (Germany)

Summary

A better understanding of stem cell biology is key to regenerative medicine and oncology alike. While adult stem cells fuel healthy tissue regeneration by indefinite self-renewal and multilineage differentiation, the accumulation of mutations specifically in stem cells is often required for cancer formation. Tissue regeneration and oncogenesis are therefore two sides of the same medal.

The Velten lab uses single-cell genomics, high-throughput genetic screens and artificial intelligence to study the regulation of differentiation programs in hematopoietic and leukemic stem cells. In the past, we have created single-cell atlases of healthy and leukemic bone marrow, we have developed new tools for high-throughput genetic screens in single cells, and we have worked on new approaches for lineage tracing in human stem cell systems. The long-term vision of our lab is to transform stem cell research into a data science discipline, and thereby enable a quantitative, predictive understanding of stem cell biology.

Currently, we are pursuing two main lines of research. Working in the healthy hematopoietic system, we use high-throughput genetic screens to unravel the logic of gene regulatory elements. Working in acute myeloid leukemia, we attempt to identify cancer stem cell specific drug targets by combining single cell transcriptomics and lineage tracing. We are passionate about integrating experimental and computational approaches in our work.

News

Single cell sequencing opens new avenues for eradicating leukemia at its source (01/03/2021).
We have published our method to identify and characterize leukemic stem cells by single cell genomics.

€2.45 m to investigate leukaemia causes and therapies (11/03/2020).
Together with partners from the University Clinics Heidelberg and the Max Delbrück Center for Molecular Medicine (Berlin), we form part of the LeukoSyStem consortium that was awarded with a prestigious junior research alliance grant by the German government.

Job Openings

We are very interested in applications of prospective postdocs and PhD students with an interest in hematopoietic stem cell biology, gene regulation, single cell genomics, single cell genetic screens and/or machine learning.

Funding acknowledgements

The project "Single cell genomics for synthetic biology of gene regulatory element" (PID2019-108082GA-I00 / AEI / 10.13039/501100011033) has received funding from the National Research Agency (Agencia Estatal de Investigación, AEI), from the Spanish Ministry of Science and Innovation.