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PRBB-CRG Sessions

PRBB-CRG SessionsPRBB-CRG Sessions

Scientific sessions of the PRBB centres funded by the Centre for Genomic Regulation (CRG) and the Barcelona Biomedical Research Park

 

07/06/202412:00MARIE CURIEPRBB-CRG SessionsArnaud KrebsEuropean Molecular Biology Laboratory (EMBL)"Cooperativity and antagonisms in transcription regulation"Host: Renee BeekmanAbstract:Transcription factors (TFs) bind at cis-regulatory elements (CREs) such as enhancers and promoters to activate transcription. In higher eukaryotes, chromatin presents a physical barrier that needs to be overcomed by TFs to access their DNA recognition motifs and activate transcription. Cooperativity is assumed to be a key mechanism for TFs to outcompete nucleosomes. Yet, the contribution of individual TFs to chromatin accessibility at CREs, and how their functions are assembled is currently...

14/06/202412:00MARIE CURIEPRBB-CRG SessionsJan LammerdingWeill Institute for Cell and Molecular Biology & Meinig School of Biomedical Engineering, Cornell University"Nuclear mechanobiology – from striated muscle disease to ultrarapid cellular mechanosensing"Host: Verena RuprechtAbstract:The nucleus is the characteristic feature of eukaryotic cells and houses the genomic information of the cell. The Lammerding laboratory is investigating how physical forces acting on the nucleus can challenge the integrity of the nucleus, alter its structure, and cause genomic, transcriptomic, and other functional changes. In this seminar, I will discuss our...

21/06/202412:00MARIE CURIEPRBB-CRG SessionsFrancis ImpensVIB & Ghent University"Host-bacteria proteomics: from antibacterial PTMs to vaccine development"Host: Eduard SabidóAbstract:The Impens lab at VIB & Ghent University, Belgium, aims to better understand the fundamental principles of host-bacteria interactions using innovative mass spectrometry (MS)-based approaches. Using Listeria monocytogenes as an intracellular bacterial model pathogen, the seminar will cover the lab’s progress to characterize protein modification by ISG15 and to develop mRNA vaccines against bacterial pathogens. ISG15 is a ubiquitin-like modification of the immune system that counteracts...

21/06/202414:30PRBB AuditoriumPRBB-CRG SessionsKazutoshi MoriInstitute for Advanced Science, Kyoto University"Dynamics of the Function and Regulation of the Endoplasmic Reticulum"Host: Vivek MalhotraAbstract:Protein unfolding and misfolding constitute a fundamental threat to all living cells. In eukaryotes, the risk of misfolding is particularly high in the endoplasmic reticulum (ER), where newly synthesized secretory and transmembrane proteins destined for the secretory pathway achieve their proper tertiary and quaternary structure. These proteins are critical for intercellular communication and their quality is maintained by chaperone-mediated productive folding...

28/06/202412:00MARIE CURIEPRBB-CRG SessionsMagda BienkoHuman Technopole and Karolinska Institute"Long-distance communication between long and short neuronal genes mediated by RNA"Host: Renée Beekman & Victoria NeguemborAbstract:Intronic sequences are spliced out of newly transcribed RNAs and are usually rapidly degraded. Because of their rapid degradation, intronic RNAs have been classically viewed as splicing by-products. Here, we integrate genome-wide maps of RNA-DNA contacts measured by RADICL-seq with genome radiality maps obtained by GPSeq, to illuminate the spatial distribution and fate of intronic RNAs in the...

05/07/202412:00MARIE CURIEPRBB-CRG SessionsAndrea CossarizzaUniversità degli Studi di Modena e Reggio Emilia"Single-cell analysis of immunometabolism: a new lens to understand human diseases"Host: Oscar FornasAbstract:In the last years, it has become more and more evident that different metabolic profiles in immune cells explain different functions, and even clinical outcomes. Importantly, to investigate the so called immunometabolism, several approaches and techniques can now be used that include spectral and mass cytometry, multiparametric cell sorting and single cell RNA sequencing, among others. In my talk, taking advantage from the aforementioned...

12/07/202412:00MARIE CURIEPRBB-CRG SessionsMaurizio ScaltritiAstraZeneca, Oncology R&D"tbc"Host: Luciano di Croce

06/09/202412:00MARIE CURIEPRBB-CRG SessionsTakashi HiiragiHubrecht Institute"Optimality for developmental robustness"Host: Adel Al Jord & Verena RuprechtAbstract:Tissue patterning depends on the coordination between cellular dynamics, fate specification and tissue morphogenesis. Understanding how precision in patterning is robustly achieved despite the inherent developmental variability remains a challenge. Our group aims to understand the design principle of multi-cellular organisms using early mammalian embryos as a model system. Our studies showed that feedbacks between cell fate, polarity and cell/tissue mechanics underlie the robust formation...