CRG Scientific Sessions
30/03/202312:00R_473.10_AULAPRBB Computational Genomics SeminarsPedro RodríguezCentro Nacional de Análisis Genómico (CNAG-CRG)"Unravelling rare diseases in Senegal (and West Africa): contributions towards diversity, equity and inclusion in genetic research."Host: Carbonell García, Rut
31/03/202310:00MARIE CURIEBioinformatics and Genomics ProgrammeRoberto CastroUniverstity of Florida Diabetes Institute. Holger Russ Lab."Modeling human autoimmune diabetes using stem cells and genetic engineering"Host: Ferrer, JorgeAbstract:Modeling human autoimmune diabetes using stem cells and genetic engineering
ß cell replacement therapy holds the promise of reversing Type 1 Diabetes (T1D) in patients. However, key challenges such as ß cell scarcity, donor incompatibility, and recurrent autoimmunity remain. In this work, we describe the optimization of a 3D directed differentiation protocol to generate an abundant source of stem-cell-derived insulin-producing ß cells (sBC). These sBC generated in the lab are functional and...
31/03/202314:00MARIE CURIESystems Biology ProgrammeDr. Chuan KuInstitute of Plant and Microbial Biology (IPMB), Academia Sinica, Taipei, Taiwan"Genomic insights into the biology of calcifying microalgae”Host: Bartomeus Cistaré, MagalíAbstract:Marine phytoplankton account for about half of the global carbon dioxide fixation and have primary productivity comparable to that of land plants. One major group of marine phytoplankton is the calcifying microalgae — coccolithophores — that are widely distributed across global oceans from the tropical to subpolar regions. In addition to their photosynthetic activity, these unicellular algae are capable of fixing dissolved inorganic carbon into calcium carbonate plates called coccoliths and thus...
11/04/202315:00R_473.10_AULACell and Developmental Biology ProgrammeDennis DischerRobert D. Bent chaired Professor, and Director of NCI-Physical Sciences Oncology Center-Project.University of Pennsyvania, Philadelphia, PA"Physically driven genetic change"Host: Pérez González, GemmaAbstract:ABSTRACT
Genetic differences are increasingly evident within tissues, tumors, and even embryos, but any contributions to such processes from the physical surroundings of cells remain obscure. Epigenetic processes in differentiation as well as nuclear mechanics are clearly modulated by tissue stiffness, and extensive sequencing also makes clear that liquid tumors and tissues have fewer genetic changes than solid tumors and tissues (regardless...
14/04/202312:00R_473.10_AULAPRBB-CRG SessionsGonçalo Castelo-BrancoLaboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden"Oligodendroglia during neural development and multiple sclerosis: insights from single-cell and spatial epigenomics"Host: Sergi ArandaAbstract:Professor Gonçalo Castelo-Branco is a Professor of Glial Cell Biology at the Department of Medical Biochemistry and Biophysics at Karolinska Institutet, Stockholm, Sweden. Prof. Castelo-Branco received his PhD in Medical Biochemistry in 2005, working on development of dopaminergic neurons and neural stem differentiation. He...
21/04/202312:00MARIE CURIEPRBB-CRG SessionsSophie DumontDept. of Bioengineering and Therapeutic Sciences, Dept. of Biochemistry and Biophysics, UCSF, San Francisco, USA"Mechanics of the kinetochore-microtubule interface: mechanisms and functions"Host: Thomas SurreyAbstract:The kinetochore links chromosomes to spindle microtubules to drive chromosome segregation at cell division. While we know nearly all mammalian kinetochore proteins, how these give rise to the kinetochore’s emergent mechanics and function remains poorly understood. First, I will discuss our work probing how kinetochores can form microtubule attachments that are at once strong yet dynamic, two...
12/05/202312:00MARIE CURIEPRBB-CRG SessionsNick J. ProudfootSir William Dunn School of Pathology, University of Oxford UK“Nascent transcription and coupled RNA processing of human protein coding and long noncoding genes”Host: Juan ValcárcelAbstract:We have developed technology to characterise nascent transcription synthesised by RNA polymerase II in human cell lines. Using the POINT-seq procedure (Sousa-Luis et al. Mol Cell 2021; doi.org/10.1016/j.molcel.2021.02.034) we show that protein coding (pc) and long noncoding (lnc) transcripts are synthesised and processed distinctly. This leads to rapid splicing of pc gene transcripts (pre-mRNA) or chromatin retention and degradation of lncRNA (recent review: Nojima and Proudfoot NRMCB 2022...
26/05/202312:00MARIE CURIEPRBB-CRG SessionsDavid M. GilbertLaboratory of Chromosome Replication and Epigenome Regulation, San Diego Biomedical Research Institute, CA, USA"Regulation of Replication Timing and Chromosome Architecture"Host: Roderic GuigóAbstract:The mammalian genome is replicated in a defined temporal sequence during S phase of each cell cycle known as the replication timing program. Since chromatin is assembled at the replication fork, and different types of chromatin are assembled at different times, replication timing is positioned to be central to maintenance or alteration of chromatin states. We have found that replication timing is a highly stable cell-type...
02/06/202312:00MARIE CURIEPRBB-CRG SessionsLiam HoltAssociate Professor, Institute for Systems Genetics, New York University School of Medicine, USA"Crowding, compression, and condensation"Host: Elvan BökeAbstract:Thousands of biochemical reactions occur simultaneously in the cell. Small molecules are channeled through metabolic pathways at blistering speed. Giant complexes assemble to orchestrate transcription and translation. ATP fuels the active transport of organelles along microtubules, and actin networks drive membrane remodeling and agitate the cytoplasm. All of this occurs within a crowded cell interior that approaches the physical limits where molecular jamming and...
16/06/202312:00MARIE CURIEPRBB-CRG SessionsHenrique Veiga-FernandesImmunophysiology Group, Champalimaud Centre for the Unknown, Lisbon, Portugal"tbd"Host: Pia Cosma
07/07/202312:00MARIE CURIEPRBB-CRG SessionsDirk SchubelerFMI, Basel, Switzerland"tbd"Host: Renee Beekman
15/12/202312:00MARIE CURIEPRBB-CRG SessionsCeline VallotInstitut Curie, Paris, France"tbd"Host: Renee Beekman