CRG Scientific Sessions
11/10/201912:00MARIE CURIEPRBB-CRG SessionsNorman DaveyUniversity College Dublin, IE"Understanding the functional role of the intrinsically disordered proteome"Host: Cedric Notredame (CRG)Abstract:Many proteins harbour extensive regions that lack stable secondary or tertiary structure in their native unbound states. These protein segments, known as intrinsically disordered regions (IDRs), are predicted to constitute up to 40% of the residues in higher eukaryotic proteomes. IDRs engage in diverse sets of activities that include providing enzyme docking sites regulating protein modification states, controlling protein stability (by recruiting ubiquitin ligases), acting...
14/10/201911:00PRBB AuditoriumOther SeminarsSusan M. GasserFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland“Dark side of the genome: how heterochromatin ensures genome stability and germline integrity”
14/10/201912:00MARIE CURIEPRBB-CRG SessionsNicola J. CurtinInstitute for Ageing, Newcastle University. Newcastle upon Tyne, UK"The development of Rucaparib (Rubraca): A story of the synergy between science and serendipityHost: José Yélamos (IMIM)
15/10/201912:00631Systems Biology ProgrammeToni BeltranMRC London Institute of Medical Sciences/Imperial College London"piRNAs: from evolution to transgenerational epigenetics"Host: Lehner, BenAbstract:Piwi-interacting RNAs (piRNAs) are a class of small RNAs expressed in the germline of metazoans that function in transposable element (TE) repression to ensure genomic integrity. In this talk, I will discuss two aspects of piRNA biology focusing on the model nematode C. elegans. First, I will describe the evolution of nematode piRNAs, and I will demonstrate how the origin and evolution of the pathway can provide insights on the mechanisms of piRNA biogenesis. In the second part of the talk, I will focus on the ability of piRNAs and...
17/10/201912:00R_473.10_AULAPRBB Computational Genomics SeminarsArnau Sebé-PedrósSingle cell genomics and evolution, CRG (Sebé-Pedrós lab)Comparative approaches to cell type evolution and regulationHost: Garrido Enamorado, Romina
18/10/201912:00PRBB AuditoriumPRBB-CRG SessionsYoshihide HayashizakiPreventive Medicine and Diagnosis Innovation Program RIKEN, JP"Recent progress in omics science by The International FANTOM Consortium"Host: Roderic Guigó (CRG)Abstract:Since the year 2000, more than 1000 scientists from various research fields have taken part in the FANTOM Consortium to analyse omics data produced by technologies that we have developed. This includes a series of applications of our full-length cDNA technology, and more recently, expression profiling using CAGE (cap-analysis gene expression). For each phase of the FANTOM project, we generated a large-scale dataset using our...
08/11/201912:00MARIE CURIEPRBB-CRG SessionsCarl-Phillip HeinsenbergIST Austria"to be determined"Host: Verena Ruprecht (CRG)
11/11/201912:00MARIE CURIEPRBB-CRG SessionsMike FeoloNational Center for Biotechnology Information, US"dbGaP: Data and Data processing"Host: Jordi Rambla (CRG)Abstract:The National Center for Biotechnology Information (NCBI) database of Genotypes and Phenotypes (dbGaP) provides unprecedented access to very large genetic and phenotypic datasets funded by the U.S. National Institutes of Health, and other funding agencies worldwide. Through controlled access, approved researchers from across the globe may obtain access to complete statistical analyses, individual phenotype information and molecular data. This presentation will summarize the data content, technical and biological...
18/11/201912:00MARIE CURIEPRBB-CRG SessionsNaama BarkaiWeizmann Institute of Science, IL"to be determined"Host: Postdoc students
22/11/201912:00MARIE CURIEPRBB-CRG SessionsPhilippe SanseauHead Computational Biology, GSK, UK"Use of highly-dimensional genetics and genomics data for drug discovery"Host: Roderic Guigó (CRG)Abstract:Drug discovery and development remains a very long and costly process. The majority of projects will fail due to lack of efficacy or because of safety concerns. This could happen at multiple stages but the later it is, the more expensive is the failure. Therefore, the choice of drug targets is very important since the outcome might not be known for many years. We have shown that using human genetics information may increase the chance of success in the clinic for new drug targets. In addition, the new functional genomics technologies...
25/11/201912:00MARIE CURIEPRBB-CRG SessionsAshby J. MorrisonDepartment of Biology, Stanford Biology, US"Epigenetic Regulation of Carcinogen Susceptibility"Host: Ben Lehner (CRG)Abstract:The development of many sporadic cancers is directly initiated by carcinogen exposure. Despite this knowledge, there has been remarkably little investigation into the factors that regulate susceptibility to acquire carcinogen-induced DNA lesions. Our research identifies the epigenetic regulators of carcinogen susceptibility and establish it as an origin of genome instability that mirrors mutagenesis in cancer.
27/11/201915:00RAMÓN Y CAJALGene Regulation,Stem Cells&Cancer Progr.Jennifer MitchellAssociate Professor, Department of Cell and Systems Biology, University of Toronto. Canada"Using CRISPR genome editing and comparative epigenomics to determine the transcriptional regulatory code for pluripotent stem cells"Host: Cosma, Maria Pia
29/11/201912:00MARIE CURIEPRBB-CRG SessionsInbal GoshenThe Edmond & Lily Safra, Centre for Brain Sciences, The Hebrew University of Jerusalemto be determinedHost: Mara Dierssen (CRG)
13/12/201912:00MARIE CURIEPRBB-CRG SessionsJitu MayorNational Centre for Biological Sciences, Bangalore, India"to be determined"Host: Vivek Malhotra (CRG)
16/12/201912:00MARIE CURIEPRBB-CRG SessionsCédric BlanpainWELBIO, Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, BE"to be determined"Host: Antoni Celià Terrassa (IMIM)
17/01/202012:00MARIE CURIEPRBB-CRG SessionsGunter MeisterUniversity of Regensburg, DEto be determinedHost: Fátima Gebauer (CRG)
24/01/202012:00MARIE CURIEPRBB-CRG SessionsIgor UlitskyWeizmann Institute of Science, Rehovot, IL"Functions and modes of action of long noncoding RNAs in mammalian cells"Host: Jorge FerrerAbstract:We are interested in understanding the codes that drive the functions of long noncoding RNAs (lncRNAs) in mammalian cells. It is now well appreciated that the human genome encodes tens of thousands of distinct lncRNA transcripts, and an increasing number are implicated as regulators in critical pathways in health and disease. The mechanisms underlying their activity, to what extent these rely on specific sequences or structures, and how they are...
31/01/202012:00MARIE CURIEPRBB-CRG SessionsNicole SoranzoWellcome Sanger Institute, Hinxton, UK"to be determined"Host: Roderic Guigó
21/02/202012:00MARIE CURIEPRBB-CRG SessionsSimon AlbertiMax Planck Institute of Molecular Cell Biology and Genetics (MPI-CBd), Dresden, Germany"to be determined"Host: Sebastian Maurer
28/02/202012:00MARIE CURIEPRBB-CRG SessionsMichael KieblerBioMedizinisches Centrum, Lehrstuhl Zellbiologie (Anatomie III), LMU, Martinsried, Germany"to be determined"Host: Fátima Gebauer and Sebastian Maurer
06/03/202012:00MARIE CURIEPRBB-CRG SessionsHeiko LickertHelmholtz Zentrum München GmbH, Institute of Diabetes & Regeneration Research, Helmholtz Diabetes Centre, Germany"to be determined"Host: Jorge Ferrer
13/03/202012:00MARIE CURIEPRBB-CRG SessionsRab PrinjhaVP, Head of Epinova Epigenetics DPU, VP Head of Epigenetics DPU (Immuno- and Cancer-Epigenetics), GlaxoSmithKline, UK"to be determined"Host: Luciano Di Croce
20/03/202012:00MARIE CURIEPRBB-CRG SessionsErin ShcumanMax Planck Institute for Brain Research, Frankfurt, DE"to be determined"Host: Juan Valcárcel
27/03/202012:00MARIE CURIEPRBB-CRG SessionsJames HackettEMBL Rome, IT"to be determined"Host: CRG PhD Students
03/04/202012:00MARIE CURIEPRBB-CRG SessionsIñigo MartincorenaWellcome Sanger Institute, Hinxton, UK"to be determined"Host: CRG PhD Students
16/10/202012:00MARIE CURIEPRBB-CRG SessionsAnne Ferguson-SmithUniversity of Cambridge. Department of Genetics"to be determined"Host: Bernhard Payer