PRBB-CRG Sessions Elisa Oricchio

23/10/202612:00MARIE CURIEPRBB-CRG SessionsElisa OricchioEPFL"Chromatin Remodeling as a Mechanism of Cancer Evolution"Host: Renée BeekmanAbstract:Cancer is a disease that adapts and evolves in response to various growth conditions and environmental signals through genetic, epigenetic, and transcriptional modifications. The genetic evolution of a tumor occurs as a result of the gradual accumulation of genomic alterations, such as mutations and chromosomal abnormalities. However, tumors can continue to progress and develop resistance to treatments even without acquiring new genetic lesions, underscoring the importance of non-genetic mechanisms in tumor evolution. In my laboratory, we are interested in understanding the interplay between genetic and epigenetic mechanisms and how they influence tumor initiation and response to anti-cancer therapies. In particular, over the past years, we have determined how cancer cells co-opt the three-dimensional (3D) structure of the chromatin in the nucleus and how histone post-translational modifications support tumor development and progression. Moreover, we are interested in understanding how the acquisition of specific genomic alterations changes the interaction between cancer cells and the tumor microenvironment. By integrating these different layers of tumor biology, we designed and propose new therapeutic interventions.