Structural Genomics

Structural Genomics

Gene Regulation, Stem Cells and Cancer

Structural Genomics

Group leader
j

Structural Genomics

Group leader
j

1999 PhD Institut de Biologia Fonamental, Universitat Autònoma de Barcelona (Spain)
1999-2003 Postdoctoral work at the Rockefeller University, New York (NY, USA).
2003-2006 Assistant Adjunct Professor, UCSF, San Francisco (CA, USA)
2006-2011 Group Leader at the CIPF, Valencia (Spain)
2012-today Group Leader at the CNAG-CRG, Barcelona (Spain)
2012-today Affiliated Group Leader to the CRG, Barcelona (Spain)
2013-today ICREA Research Professor

  
Our group web site: http://www.marciuslab.org

We are interested in the molecular mechanisms that regulate cell fate. To study such mechanisms, we employ the laws of physics and the rules of evolution to develop and apply computational methods for predicting the 3D structures of macromolecules and their complexes. Our current lines of research are:

Open Source drug discovery projects for tropical diseases
We develop methods for comparative docking of small chemical compounds and their target proteins. Such methods have already been applied to identify drug targets in ten genomes that cause tropical diseases. This work is part of the Tropical Disease Initiative and is funded by the Spanish Ministerio de Ciencia e Innovación.

RNA structure prediction
The recent interest in RNA, specially non-coding RNA molecules, has prompted us to develop a series of tools for the alignment of RNA structures and the prediction of their functions. This work has been funded by a Marie Curie action and a Generalitat Valenciana research grant.

Structure determination of genomes
More recently, we have engaged collaboration with experimentalists to study the 3D organization of the chromatin. Such work is resulting in the first ever structures of genomic domains and entire genomes.

 

ERC Synergy Project - Dynamics of Genome Architecture in Stable and Transient Changes in Gene Expression

Chromosomes and genes are non-randomly positioned in the cell nucleus and the vision of a dynamic and complex organization of the nucleus is replacing the classical view of genomes as linear sequences. (+more info)