TANGO2 mutations initiate fatal metabolic crises. The gene’s role in lipid metabolism and energy production explains why. 

Findings shed light on how cells secrete just the right amount of the two proteins crucial for human health

Findings can lead to new strategies to accelerate or manipulate the molecular mechanisms involved to target cancer
 

Cells use editing tools to skip or rearrange information stored in DNA. A 10-million-euro ERC Synergy Grant will explore how to control this process with molecular precision.

In crisis, the nucleus calls antioxidant enzymes to the rescue. This indicates metabolic activity, which would be a profound paradigm shift with implications for cancer research.

Di Croce lab's group will leverage their expertise to help study the most frequent type of cancer

Dr. Lehner is recognised for his exceptional contributions to the advancement of biomedical and health science

Dr. Lehner is one of 80 scientists - and only one based in Spain - to be recognised by the prestigous national scientific academy of the UK

A European Innovation Council-funded project aims to quantify a cancer cell’s plasticity
 

The findings pave the way for the development of new techniques to predict how AML patients will respond to chemotherapy.