Inicio

Stammnitz Lab

Stammnitz LabStammnitz Lab

Quantitative Cell Biology

  • Group page
  • Research lines
  • Group members
  • Publications
Quantitative Cell Biology
Independent Fellow
Stammnitz Lab

Quantitative Cell Biology

Independent Fellow
Stammnitz Lab
ORCID iD https://orcid.org/0000-0002-1704-9199

Biosketch

2027, Independent Fellow, CRG (Spain) and AR+I (Andorra)
2026, Staff Scientist, Ferruz Lab, CRG (Spain)
2022-2026, EMBO and Marie Skłodowska-Curie Postdoc Fellow, CRG (Spain)
2015-2022, PhD and Bridge Postdoc in Genomics, University of Cambridge (UK).
2014-2015, MPhil in Computational Biology, University of Cambridge (UK)
2011-2014, BSc in Biology, University of Freiburg (Germany)

Summary

How do proteins evolve to sense environmental chemistry with extreme specificity and sensitivity? Can we decode the molecular determinants by which these structures are tuned and engineered? In our group, we perform large-scale protein library screens to determine proteins’ small molecule interaction profiles (e.g. see Stammnitz & Lehner, Nature Communications 2026). We test thousands of hormone receptors from plants to humans, as well as anti-fungal and ‘molecular glue’ compounds which chemically modulate their protein targets. With the help of these functional genomics experiments, AI-enhanced evolutionary inference and protein structure modelling, our goal is to design a range of new biosensors for the scalable monitoring of invisible chemicals – this holds key applications for One Health.

We are a small and multidisciplinary team. Together with Hannah Benisty’s group and our partners at AR+I, we are the founding team of the new joint green biotechnology and environmental monitoring initiative between CRG and the Principality of Andorra.

Software

nf-core/deepmutscan: a reproducible, scalable, and community-curated pipeline for analyzing deep mutational scanning (DMS) data using shotgun DNA sequencing

Job Openings

We are recruiting PhD candidates via CRG’s international call. Please get in touch by email if you would like to hear more about our research opportunities, or if you are considering joining in another role (e.g. for a Master’s thesis). We encourage self-motivated candidates and are always happy to discuss your own project ideas in the context of chemical biology, protein engineering, experimental and computational genomics.

Group Leader

SELECTED PUBLICATIONS:

 

**Joint-first Author
§Corresponding Author

 

M.R. Stammnitz, B. Lehner§
The genetic architecture of an allosteric hormone receptor.
Nature Communications 17, 4735 (2026). 10.1038/s41467-026-70341-2
O. Nousias*, M. McCauley*, M. R. Stammnitz*, …, D. J. Duffy§,
Shotgun sequencing of airborne eDNA achieves rapid assessment of whole biomes, population genetics and genomic variation
Nature Ecology & Evolution 9, 1043-1060 (2025). 10.1038/s41559-025-02711-w
M. R. Stammnitz§, A. Hartman Scholz, D. J. Duffy
Environmental DNA without borders
EMBO Reports 25, 4095-4099 (2024). 10.1038/s44319-024-00264-w
M. R. Stammnitz, K. Gori, Y. M. Kwon, …, E. P. Murchison§,
The evolution of two transmissible cancers in Tasmanian devils.
Science 380, 283–293 (2023). 10.1126/science.abq6453
L. Urban*,§, A. Holzer*,§, J. J. Baronas, …, M. R. Stammnitz§,
Freshwater monitoring by nanopore sequencing.
eLife 10, e61504 (2021). 10.7554/eLife.61504
M. R. Stammnitz, T. H. H. Coorens, K. Gori, …, E. P. Murchison§,
The origins and vulnerabilities of two transmissible cancers in Tasmanian devils.
Cancer Cell 33, 607–619 (2018). 10.1016/j.ccell.2018.03.013