Coordination of Cytokinesis with Chromosome Segregation

Coordination of Cytokinesis with Chromosome Segregation

Cell and Developmental Biology

Coordination of Cytokinesis with Chromosome Segregation

Group leader
j

Coordination of Cytokinesis with Chromosome Segregation

Group leader
j

1997-2002: Graduate student in the laboratory of Michael Glotzer, Institute of Molecular Pathology (IMP) Vienna, Austria.
2002: PhD in Biochemistry, University of Vienna.
2002- 2004: Postdoctoral Fellow in the laboratory of Damian Brunner, European Molecular Biology. Laboratory (EMBL), Heidelberg, Germany.
2004-2008: Postdoctoral Fellow in the laboratory of Yves Barral, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland.
From July 2008: Group Leader at the Center for Genomic Regulation (CRG) Barcelona, Spain.

Summary

Living cells have a fascinating ability to generate complex and dynamic internal structures. Nowhere is this property more evident than during mitosis and cytokinesis: in a very short time (often of the order of a few minutes) cells alter their shape, duplicate and partition their internal components, and divide into two apparently identical halves.

These dramatic morphological changes need to be carefully coordinated with each other in space and time.

To learn more about the principles underlying this coordination, we focus on the events at the end of the cell cycle: chromosome segregation and cytokinesis, in the yeast Saccharomyces cerevisiae.

Regulatory systems identified in yeast are then validated in animal cells (such as Drosophila), to ensure that our key findings are relevant for the fidelity of mitosis and genetic stability in multicellular organisms