Cellular & Systems Neurobiology

Cellular & Systems Neurobiology

Systems Biology

Cellular & Systems Neurobiology

Group leader

Cellular & Systems Neurobiology

Group leader

1989 Ph.D. Department of Physiology and Pharmacology, Universidad de Cantabria (Spain).
1990-1993 Postdoctoral work at the Universidad Autònoma de Barcelona (Spain).
1993-1997 Assistant Professor at the Universidad de Cantabria (Spain).
1997-2001 Research position. Medical and Molecular Genetics Center-Institut de Recerca Oncológica (IRO), Barcelona (Spain).
2001-Present Group Leader at the Center for Genomic Regulation, Barcelona (Spain).

Group news

Mara Dierssen awarded the Big Vang Medal (16/06/2017)

Mara Dierssen elected president Trisomy 21 Society (11/11/2016)

Mara Dierssen new Distinguished Alumni of the University of Cantabria (18/06/2015)

Dierssen lab publishes translational research discovering a precognitive therapy for Down syndrome in Lancet Neurology (07/06/2016)

Gene Linked to Down Syndrome Associated With Altered Oscillations in Cerebral Cortex (05/04/2016)


The main research interest in my laboratory is to decipher brain mechanisms sub serving learning and memory, and how they are altered in cognitive pathology. We aim at understanding how the neuronal architecture and connectivity constrain the mesoscopic network activity and influences the flow and storage of information in neuronal circuits in cognitive-related disorders. We use behavioural, molecular and structural techniques in genetically modified model organisms to interrogate basic principles of intellectual disability. Also, we obtain structural experimental data from cleared brains which constrain computational modelling and analysis tools to explore the neuronal circuit topologies to understand the organizational principles of mammalian neuronal networks. Finally, we are interested in applying all this knowledge to develop new therapeutic tools targeting neural plasticity which rewire molecular networks, including epigenomic state, to recover impaired structural and functional features in cognitive pathology.

Impact of impaired molecular network and structural connectivity on cognitive-related disorders

Study of neuronal circuit topologies to decipher the organization of neuronal networks

Other Activities

TEDxSantCugat - Mara Dierssen - La fuerza de la diferencia (in Spanish)
Brain Polyphony Concert 10 December 2016
Neuroscience Christmas Symposium 21 December 2016
International Master Degree in Neurosciences
TEDxSol - Mara Dierssen - Cómo podemos fabricar un entorno que cambie nuestro cerebro (in Spanish)