Cellular & Systems Neurobiology

Cellular & Systems Neurobiology

Systems Biology

Cellular & Systems Neurobiology

Group leader

Cellular & Systems Neurobiology

Group leader

1989 Ph.D. Department of Physiology and Pharmacology, Universidad de Cantabria (Spain).
1990-1993 Postdoctoral work at the Universidad Autònoma de Barcelona (Spain).
1993-1997 Assistant Professor at the Universidad de Cantabria (Spain).
1997-2001 Research position. Medical and Molecular Genetics Center-Institut de Recerca Oncológica (IRO), Barcelona (Spain).
2001-Present Group Leader at the Center for Genomic Regulation, Barcelona (Spain).

Group news

Mara Dierssen awarded the Big Vang Medal (16/06/2017)

Mara Dierssen receives the Trifermed award (09/06/2017)

Mara Dierssen elected president Trisomy 21 Society (11/11/2016)

Mara Dierssen Distinguished Alumni of the University of Cantabria (18/06/2015)

Dierssen lab publishes translational research discovering a pro-cognitive therapy for Down syndrome in Lancet Neurology (07/06/2016)
New research published in Lancet Neurology has found using a inhibitor of DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase DYRK1A), a serine/threonine kinase involved in brain plasticity, in combination with cognitive training improves some measures of cognition and behavior in subjects with Down syndrome.

Gene Linked to Down Syndrome Associated With Altered Oscillations in Cerebral Cortex (05/04/2016)
Scientists at the CRG and IDIBAPS in Barcelona, Spain, have made a first-ever identification of the alterations in the neuronal circuit that impact cerebral cortex physiology.

The Institució CERCA launches a video that walks you through several types of conversation in a mock evaluation panel that hinder objectivity towards candidates 
The CERCA centers diversity commission, chaired by Mara Dierssen has drawn up a pioneering tool to inform faculty, both men and women, that shows bias in evaluation, which is particularly detrimental to women.


Dierssen’s lab is centered on understanding cognition and behavior as emergent properties of neuronal networks. The main question is how the neuronal architecture and connectivity constrain the mesoscopic network activity and influences the flow and storage of information in cortical and hippocampal circuits. In the last years, we have studied the mechanisms of information transfer in cortical circuits at different scales: from the single cell and molecular levels to the neuronal population level. A good model which captures the relevance of this study is cognitive disorder, because it refers to functional alterations that are accompanied by structural changes. Our systematic and wide-angled approach with different levels of description, needs building mathematical description and data-driven computational modeling that enable us to link changes in structural and molecular changes in functional units, to their effects on neuronal spiking activity and evoked cortical dynamics during information processing. 

Other Activities

TEDxSantCugat - Mara Dierssen - La fuerza de la diferencia (in Spanish)
Brain Polyphony Concert 10 December 2016
Neuroscience Christmas Symposium 21 December 2016
International Master Degree in Neurosciences
TEDxSol - Mara Dierssen - Cómo podemos fabricar un entorno que cambie nuestro cerebro (in Spanish)