Microtubule function and cell division
Cell and Developmental Biology
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1989 PhD, Dpt of Biochemistry, Medical School, Universidad Autónoma de Madrid (Spain)
1989-1992 Postdoctoral work at the University of Cambridge and The Wellcome/CRC Institute, Cambridge, UK.
1992-1996 Postdoctoral work at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
1996-2001 Staff Scientist at EMBL
2001-2005 Team Leader at EMBL
August 2005 ICREA Reseach Professor and Group Leader at the Centre de Regulació Genòmica, Barcelona (Spain).
Research in my lab is directed at understanding the role of the microtubule network in cell organization and function. To address this question we study various microtubule-associated proteins (molecular motors and MAPs) and their regulators (kinases, phosphatases and the small GTPase Ran during M-phase). One major goal is to unravel how the self-organization of cellular components results in the morphogenesis of dynamic molecular machines. At present we are focusing on one example of self-organization: the assembly of the bipolar spindle in mitosis and meiosis.
Our favorite experimental system is the Xenopus egg extract system for studies on cell cycle progression and regulation, microtubule dynamics, spindle assembly and chromosome behaviour (Karsenti and Vernos, 2001). We combine it with the use of human tissue culture cells in which we validate some of the results obtained in egg extract.