PRBB-CRG Sessions Nicola Ternette

06/11/202612:00PRBB AuditoriumPRBB-CRG SessionsNicola TernetteUniversity of Dundee"Redefining the HLA-E Immunopeptidome - a new landscape for therapeutic targeting"Host: Eduard SabidóAbstract:HLA-E is a non-classical HLA molecule with limited polymorphism, making it an attractive candidate for broadly applicable immunotherapeutic targeting. Its peptide repertoire, however, remains poorly understood. Using immunopeptidomics, machine-learning assisted prediction, and biochemical validation, we uncover an extended HLA-E immunopeptidome comprising canonical and non-canonical peptides, including cancer-associated ligands shared across individuals and tumour types. These findings challenge the traditional view of HLA-E antigen presentation and reveal new opportunities to exploit HLA-E-presented peptides for therapeutic targeting in cancer.