Scientific sessions of the PRBB centres funded by the Centre for Genomic Regulation (CRG) and the Barcelona Biomedical Research Park
20/01/201712:00MARIE CURIEPRBB-CRG SessionsAdrian BrackenTrinity College Dublin, Ireland"Polycomb Repressive Complex 2 in Stem Cells and Cancer"Host: Luciano di Croce (CRG)Abstract:
The Polycomb Repressive Complex 2 (PRC2) is a multiprotein chromatin modifying complex that is essential for vertebrate development and differentiation. It is composed of a trimeric core of SUZ12, EED and EZH1/2 and is responsible for catalysing both di- and tri- methylation of Histone H3 at lysine 27 (H3K27me2/3). Both H3K27 methylations contribute to the role of PRC2 in maintaining cellular identity. In all cell types, the H3K27me3 modification is associated with repression of genes...