Gene dosage and gene duplication

Gene dosage and gene duplication


Everyone knows that gene duplications are of paramount importance for the emergence of new genes and new gene functions. Over the past century, many formal and verbal theories have been put forth to describe the process of evolution of new functions through gene duplications. More recently, completely sequenced genomes yielded the necessary data to start testing the theoretical expectations. We strive to understand the early stages in the life of gene duplications, and what forces, neutral or selective, lead to the fixation of a new gene copy. In essence, we try to understand what factors turn copy number variants (copy polymorphisms) into fixed gene duplications. We have found that recently fixed gene duplications preferentially code for dosage-sensitive functions that may be involved in organism-environment interactions, such as stress response, nutrient limitation or organic and inorganic toxicity response. To describe this phenomenon, we have unified the classic theory of genetic dominance first postulated by Sewal Wright with the theory of gene duplications. We postulate, that gene dosage plays an important role in the fixation and early maintenance of gene duplications, and probably is the basis of different frequencies of copy number variants in various populations.

Relevant publications
Kondrashov FA , Gurbich TA and Vlasov PK (2007). Selection for functional uniformity of tuf duplicates in gamma-proteobacteria. Trends in Genetics 23, 215-218

Kondrashov FA and Kondrashov AS. (2006) Causes of fixation of duplicated genes. Journal of Theoretical Biology 239, 141-151.

Kondrashov FA and Koonin EV. (2004) A common framework for understanding the origin of genetic dominance and evolutionary fates of gene duplications. Trends in Genetics 20, 287-290.

Kondrashov FA, Rogozin IB, Wolf YI and Koonin EV. (2002) Selection in the evolution of gene duplications. Genome Biology 3, research0008.1-0008.9