Regulation of Protein Synthesis in Eukaryotes
Gene Regulation, Stem Cells and Cancer
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1990 PhD in Biological Sciences by the Department of Biochemistry and Molecular Biology, Autónoma University of Madrid (Spain).
1992-1996 Postdoctoral Research Associate in Joel D. Richter's laboratory. Worcester Foundation for Biomedical Research, Massachusetts (USA).
1996-2000 Postdoctoral Research Associate in Matthias W. Hentze's laboratory. European Molecular Biology Laboratory - EMBL-, (Germany).
2001 Staff Scientist at EMBL.
2002 Group Leader at the Center for Genomic Regulation - CRG- Barcelona (Spain).
Our group is interested in the regulation of mRNA translation by RNA-binding proteins (RBPs) and by elongation of the mRNA poly(A) tail. This type of regulation is widely used in Biology to modulate processes such as metabolism, cell differentiation, embryonic patterning or synaptic transmission. We wish to understand the molecular mechanisms of translational control and the RNA networks that are established to maintain cell homeostasis. We are interested on how de-regulation of RBP function leads to disease, in particular to cancer.
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We acknowledge the financial contribution of the Spanish Ministry of Science and Technology and the European Regional Development Fund (ERDF) to the development of the project “Regulation of mRNA specific translation” (Ref. BFU2006-01874). We also acknowledge the contribution of DURSI (Ref. 2005SGR00669).