CRG Scientific Sessions
31/10/202512:00MARIE CURIEPRBB-CRG SessionsKristen VerheyUniversity of Michigan Medical School"Dynamics and structural changes within the microtubule lattice"Host: Thomas SurreyAbstract:Microtubules are cytoskeletal filaments that self-assemble from the protein tubulin and are critical for a variety of important functions in eukaryotic cells, including cell mechanics, migration, and division. Much work in the field has focused on the dynamics at the ends of microtubules and specifically, how tubulin’s GTP binding and hydrolysis drives the addition and loss of tubulin subunits at the ends. However, an emerging idea in the field is that the structure...
04/11/202510:00473.10Other SeminarsJames William BrysonKØBENHAVNS UNIVERSITET, BRIC“Extending the tools for gene expression regulation and exploring epitranscriptomic translational regulation”Host: Jurado Calero, IsabelAbstract:Tools for gene expression regulation have rapidly expanded beyond the traditional Cas9. More recent generations of CRISPR variants offer invaluable properties for robust and multiplexed regulation of gene expression. Here the development of Cas12 and Cas13 derived CRISPR tools are discussed alongside a computational tool for facilitating the targeting crRNA design and assembly. We are subsequently employing Cas12 to systematically screen the influence of small nucleolar RNAs, responsible for laying...
14/11/202512:00MARIE CURIEPRBB-CRG SessionsAlexander van OudenaardenHubrecht Institute"TBC"Host: Renee Beekman
04/12/202512:00PRBB AuditoriumPRBB-CRG SessionsKathryn LilleySubcellular proteome and transcriptome, Department of Biochemistry, University of Cambridge"Unveiling the Subcellular Complexity: Beyond Protein Expression"Host: Eduard SabidóAbstract:Biological systems function through intricate regulatory networks that go far beyond simple changes in protein levels. These networks involve multiple layers of sophisticated multi-omics control, including non-coding RNA regulation, post-transcriptional and post-translational modifications, and dynamic subcellular localization. Many of these regulatory mechanisms rely on the dynamic interplay between proteins and RNA...