CRG Scientific Sessions

14/10/202612:00MARIE CURIECBHG Program SeminarAnthony BrookersUniversity of Leicester"Discovering Data Discovery Solutions"Host: Ferrer, JorgeAbstract:In biomedicine, there is a clear imperative to ensure that datasets are used, shared, and reused to their full potential. This is expressed through the FAIR data principles: that data should be Findable, Accessible, Interoperable, and Reusable. However, the apparent simplicity of the FAIR acronym belies the considerable complexity involved in translating these principles into practice. The first and most fundamental requirement entails making datasets discoverable, i.e., Findable. If researchers cannot establish that a relevant dataset exists, they will never undertake subsequent steps...

23/10/202612:00MARIE CURIEPRBB-CRG SessionsElisa OricchioEPFL"TBC"Host: Renée Beekman

06/11/202612:00PRBB AuditoriumPRBB-CRG SessionsNicola TernetteUniversity of Dundee"Redefining the HLA-E Immunopeptidome - a new landscape for therapeutic targeting"Host: Eduard SabidóAbstract:HLA-E is a non-classical HLA molecule with limited polymorphism, making it an attractive candidate for broadly applicable immunotherapeutic targeting. Its peptide repertoire, however, remains poorly understood. Using immunopeptidomics, machine-learning assisted prediction, and biochemical validation, we uncover an extended HLA-E immunopeptidome comprising canonical and non-canonical peptides, including cancer-associated ligands shared across individuals and tumour types....