CRG Scientific Sessions
30/03/201712:00R_473.10_AULAPRBB Computational Genomics SeminarsYannick SpillStructural Gemomics, CNAG-CRG / Dynamical Systems Biology, UPFBase-resolution view, normalization and binless representation of Hi-C dataHost: Garrido Enamorado, RominaAbstract:Yannick Spill (Marc Marti Renom lab)
Structural Gemomics, CNAG-CRG
"Base-resolution view, normalization and binless representation of Hi-C data"
3C-like experiments, such as 4C or Hi-C, have been fundamental in understanding
genome organization at the gene level. Of prime importance, TADs and chromatin
loops are implicated in the dynamic interplay of gene activation and repression, and
their disruption can have dramatic effects on...
31/03/201712:00R_473.10_AULAPRBB-CRG SessionsStefan BonnDeutsches Zentrum für Neurodegenerative Erkrankungen in der Helmholtz-Gemeinschaft, DE"Taking a systems look at (Neurodegenerative) diseases"Host: Mara Dierssen (CRG)Abstract:In the last decade technological improvements gave rise to unprecedented amounts of quantitative information about biological entities and processes, including thousands of genomic, proteomic, and transcriptomic datasets. Given this wealth of available information, can we use this data to understand and predict biological processes computationally? In my talk I will highlight two recent efforts of our lab to predict human disease and basic...
07/04/201712:00MARIE CURIEPRBB-CRG SessionsVictor CorcesDepartment of Biology, Emory University"Evolutionarily Conserved Principles Predict 3D Chromatin Organization"Host: François Le Dily (CRG)Abstract:
Compartments, TADs, and CTCF loop domains have been identified as important structural and functional components of 3D chromatin organization, yet the relationship between these features is not well understood. Here we show that chromatin is organized by a hierarchy of interactions primarily determined by transcription. Indeed, transcription is a major predictor of Hi-C contact maps in all tested eukaryotes, including C. elegans and A. thaliana....
28/04/201710:00R_473.10_AULACell and Developmental Biology ProgrammeYanlan MaoMRC-Laboratory for Molecular Cell Biology. University College LondonGetting in Shape: In vivo and in silico studies of tissue mechanics in growth controlHost: Solon, Jérôme
08/05/201710:00RAMÓN Y CAJALBioinformatics and Genomics ProgrammeRoland GrafströmInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden / Misvik Biology, Turku, FinlandEntering the era of ”Big Data” in toxicology: predicting adverse outcomes based on high-throughput screening (HTS) and omics-driven informaticsHost: Notredame, CedricAbstract:Mechanistic analyses of toxicity-related pathways based on data generation from HTS and omics technologies form a key to in-vitro-only safety assessment and the emerging Adverse Outcome Pathways (AOP) concept. Our laboratory applied HTS technology to rapidly rank multiple toxicity-related parameters for diverse manufactured nanomaterials, spanning carbon nanotubes, silicas...
09/05/201711:00R_473.10_AULAISA SessionsGabrielle BertierJoint PhD between the McGill Department of Human Genetics Center for Genomics and Policy in Montreal and the University Toulouse III Paul Sabatierv"Next-generation sequencing in the clinic: where are we and where are we going?”Host: Bertero, MichelaAbstract:Background: Whole-exome sequencing (WES) analyses all known exons in the human genome. Originally developed in research, this technology is increasingly used to inform patient care. The implementation of WES into healthcare poses significant organizational, regulatory, and ethical hurdles. There is little evidence to date as to how WES is used in French and Quebec clinics.
Objectives and Methods: To inform policy...
10/05/201711:00CHARLES DARWINGene Regulation,Stem Cells&Cancer Progr.Alvaro Rada-IglesiasCenter for Molecular Medicine Cologne (CMMC), University of Cologne."Poised enhancers regulatory activity is topologically facilitated by polycomb".Host: Beringer, Malte
24/05/201710:00MARIE CURIECell and Developmental Biology ProgrammePeter BielingRegulatory mechanisms of cell morphology, Max Planck Institute of Molecular PhysiologyTBCHost: Carbonell García, Rut