CRG Scientific Sessions
10/03/202615:00R_473.10_AULACell and Developmental Biology ProgrammeXiang Dong FuWestlake University"The mechanism of Aging"Host: Malhotra, VivekAbstract:The Mechanism of Aging
Xiang-Dong Fu, Westlake University
Aging is characterized by a series of hallmarks, including genome instability, epigenetic alterations, mitochondrial dysfunction, cell senescence, etc. but the cause-and-consequence relationship among these events has remained elusive. A recent report reveals accelerated transcription elongation during aging in diverse organisms from warms to humans. We confirm this by analyzing the time course of nascent RNA production on a common cellular aging model through continuous passage of mesenchymal stem cells (MSCs)....
16/03/202612:00R_473.10_AULACell and Developmental Biology ProgrammeZdenek LanskyThe Institute of Biotechnology of the Czech Academy of SciencesATP regulates tau-microtubule interactionHost: Surrey, ThomasAbstract:
Neuronal microtubule-associated protein tau can protect the microtubule surface, maintaining microtubule stability. In neurodegenerative diseases termed tauopathies, tau forms cyto-toxic aggregates presumably as a consequence of tau delocalization from microtubules, accompanied by an increase in cytoplasm-localized tau and microtubule destabilization. The underlying mechanisms, however, remain unclear. Here, we show that decline of adenosine triphosphate (ATP), related to aging and neurodegeneration, leads to tau...
16/03/202615:00R_473.10_AULACell and Developmental Biology ProgrammeLiang GeTenured Associate Professor,School of Life Sciences, Tsinghua University,BeijingStress-Induced endomembrane Remodeling: Cellular Function and DiseaseHost: Benito Mestres, Marta
17/03/202611:00UPFCell and Developmental Biology ProgrammeZoe GeragthyCRGReconstituting balance in the mitotic spindle: polar and antiparallel microtubule organisationHost: Benito Mestres, Marta
20/03/202612:00MARIE CURIEPRBB-CRG SessionsUlrike KutayInstitute of Biochemistry, ETH Zurich"Nuclear envelope function and remodelling – from heterochromatin organization to NPC biogenesis"Host: Adel Al JordAbstract:The Kutay lab investigates nuclear organization, function and dynamics in mammalian cells, including research on the biosynthetic function of the cell nucleus in the assembly of ribosomal subunits, the role of the nuclear envelope in nucleo-cytoplasmic communication and genome organization, and the dynamic remodelling of the nuclear compartment during the cell cycle.
In my talk, I will cover two aspects of our ongoing science. Firstly, I will...
27/03/202612:00MARIE CURIEPRBB-CRG SessionsAmanda WhippleHarvard University"Mechanisms of Imprinted Gene Regulation in the Brain"Host: Postdoc CommunityAbstract:Genomic imprinting is an epigenetic process that drives parent-of-origin–specific gene expression and is essential for brain development. Disruption of imprinting causes severe neurodevelopmental disorders, including Angelman and Prader–Willi syndromes. However, the mechanisms that establish and maintain allele-specific expression in neural cells remain incompletely understood.
Our lab investigates how chromatin architecture and noncoding RNAs regulate imprinted genes in the developing brain. Using allele-specific...
07/04/202615:00R_473.10_AULAGene Regulation,Stem Cells&Cancer Progr.Alex KentsisMemorial Sloan Kettering Cancer CenteTow Center for Developmental Oncology, Sloan Kettering Institute and Department of PediatricsrDevelopmental Mutators: On the origins and rational therapies of cancers in children and young adultsHost: Tagliaferro, Barbara
09/04/202615:00MARIE CURIEGene Regulation,Stem Cells&Cancer Progr.Austin SmithtbctbcHost: Tagliaferro, Barbara
10/04/202612:00MARIE CURIEPRBB-CRG SessionsGregory GibsonGeorgia Institute of Technology"Haplotype-Embedded Regulatory Variation Shapes Gene Expression and Immune Associations"Host: Arcadi NavarroAbstract:The regulation of gene expression is typically mediated by multiple independent associations each parsimoniously assumed to be due to the activity of a single causal variant. In this talk I will challenge this assumption by reporting results of experiments using expression CROPseq to fine-map regulatory potential for 4,382 SNPs in 87 loci associated with immune disease. An average of 2.3 variants contribute to each of 66 fine-mapped eQTL, with some cell-state...
17/04/202612:00MARIE CURIEPRBB-CRG SessionsAtaman SendölInstitute for Regenerative Medicine (IREM), University of Zurich"TBC"Host: Fatima Gebauer
15/05/202612:00MARIE CURIEPRBB-CRG SessionsAnders H. LundUniversity of Copenhagen"TBC"Host: Fatima Gebauer
22/05/202612:00MARIE CURIEPRBB-CRG SessionsFrancesca SpagnoliKing's College London"TBC"Host: Jorge Ferrer
26/06/202612:00MARIE CURIEPRBB-CRG SessionsGuillaume AndreyUniversité de Genève"TBC"Host: Renée Beekman
03/07/202612:00MARIE CURIEPRBB-CRG SessionsMaria BarnaStanford Medicine"TBC"Host: Fatima Gebauer
04/09/202612:00MARIE CURIEPRBB-CRG SessionsTaro KitazawaDANDRITE-Nordic-EMBL & Aarhus University"TBC"Host: Hsiu-Chuan Lin
18/09/202612:00MARIE CURIEPRBB-CRG SessionsAugustine KongOxford Big Data Institute"TBC"Host: Amelie Baud
23/10/202612:00MARIE CURIEPRBB-CRG SessionsElisa OricchioEPFL"TBC"Host: Renée Beekman
30/10/202612:00MARIE CURIEPRBB-CRG SessionsEmmanuel DeriveryMRC Laboratory of Molecular Biology"TBC"Host: Thomas Surrey & Adel Al Jord
04/12/202612:00MARIE CURIEPRBB-CRG SessionsChristine MayrMemorial Sloan Kettering Cancer Center"TBC"Host: Adel Al Jord