CRG Scientific Sessions
03/10/202512:00MARIE CURIEPRBB-CRG SessionsChristina LeslieMemorial Sloan Kettering Cancer Center"Machine learning models for single-cell and regulatory genomics"Host: Fanny Mollandin & Jorge FerrerAbstract:We will present new deep learning models that exploit single-cell multiome (scRNA+ATAC-seq) and 3D genomics data in order to link enhancers and non-coding variants to genes and to decipher gene regulatory networks. First, in collaboration with the Danwei Huangfu lab, we developed a model called GraphReg+ to integratively model (pseudobulk) multiome and HiCAR data at multiple steps of guided in vitro pancreatic differentiation of pluripotent...
06/10/202512:00R_473.10_AULACell and Developmental Biology ProgrammeLuke RiceUT Southwestern Medical Center“How to regulate microtubule transitions: Teaching a TOG new tricks”.Host: Benito Mestres, Marta
17/10/202512:00MARIE CURIEPRBB-CRG SessionsMichael HillerLOEWE Centre for Translational Biodiversity GenomicsLinking phenotypic differences between species to differences in their genomesHost: Manuel IrimiaAbstract:In the first part of the talk, I will present TOGA (Tool to infer Orthologs from Genome Alignments) version 2.0, the completely reimplemented successor to the original method that simultaneously annotates coding genes and infers orthologs. TOGA 2.0 provides several new features, among them deep learning-based splice site predictions, which enable the method to cope with exon boundary shifts and evolutionary exon-intron structure changes.
In the...
24/10/202512:00MARIE CURIECRGSabine Guth-GundelNovartis Biomedical ResearchTherapeutic potential of allosteric HECT E3 ligase inhibitionHost: Valcárcel Juárez, Juan
31/10/202512:00MARIE CURIEPRBB-CRG SessionsKristen VerheyUniversity of Michigan Medical School"TBC"Host: Thomas Surrey
14/11/202512:00MARIE CURIEPRBB-CRG SessionsAlexander van OudenaardenHubrecht Institute"TBC"Host: Renee Beekman