PRBB-CRG Sessions Kazutoshi Mori

21/06/202414:30PRBB AuditoriumPRBB-CRG SessionsKazutoshi MoriInstitute for Advanced Science, Kyoto University"Dynamics of the Function and Regulation of the Endoplasmic Reticulum"Host: Vivek MalhotraAbstract:Protein unfolding and misfolding constitute a fundamental threat to all living cells. In eukaryotes, the risk of misfolding is particularly high in the endoplasmic reticulum (ER), where newly synthesized secretory and transmembrane proteins destined for the secretory pathway achieve their proper tertiary and quaternary structure. These proteins are critical for intercellular communication and their quality is maintained by chaperone-mediated productive folding and ER-associated degradation (ERAD).
This ER quality control system, however, can be compromised under a variety of physiological and pathological conditions, resulting in ER stress characterized by the accumulation of unfolded and misfolded proteins. Nearly all eukaryotic cells cope with ER stress by activating highly sophisticated transcriptional and translational programs, collectively termed the unfolded protein response (UPR).
I will talk on the mechanism, evolution, and physiological importance of the UPR as well as its involvement in development and progression of various diseases.