Gene Regulation, Stem Cells and Cancer

Gene Regulation, Stem Cells and Cancer

Gene Regulation, Stem Cells and Cancer

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Coordinator: Juan Valcárcel

The interests of the program span from mechanisms of gene expression and epigenetic regulation to the molecular basis of cellular decisions involved in tissue homeostasis and cancer.

Mechanistic and biological studies of gene regulation span the whole pathway of gene expression, from chromatin organization in the cell nucleus to mRNA translation in the cytoplasm.  Transcriptional regulation groups study the organization and evolution of the regulatory genome (Dr. Guillaume Filion), chromatin structure and regulation mediated by steroid hormones (Dr. Miguel Beato), effects of dosage imbalance of chromosome 21 (Dr. Susana de la Luna), epigenetic mechanisms in leukemia and stem cells (Dr. Luciano Di Croce), single cell epigenomics in lymphomas (Dr. Renee Beekman) and epigenetic regulation of cancer metabolism (Dr. Sara Sdelci). RNA biology groups study the identification and control of RNA modifications (Dr. Eva Novoa), the regulation of alternative splicing (Dr. Juan Valcárcel) and the regulation of cytoplasmic polyadenylation and mRNA translation (Dr. Fátima Gebauer). 

Cell reprogramming studies include differentiation and transdifferentiation in the hematopoietic system (Dr. Thomas Graf), and somatic cell reprogramming and tissue regeneration by cell fusion (Dr. Maria Pia Cosma) and epigenetic reprogramming in embryogenesis and the germline (Dr. Bernhard Payer).

SOCIAL ACTIVITIES: The program’s retreat, November 2019 (pictures and video)

SOCIAL ACTIVITIES: The program’s retreat, November 2016 (pictures)

SOCIAL ACTIVITIES: The program’s retreat, October 2013 (pictures)

GROUPS

Juan Valcárcel Juárez
Thomas Graf
Miguel Beato del Rosal
Luciano Di Croce
Maria Pia Cosma
Fátima Gebauer
Susana De la Luna Gargantilla
Guillaume Filion
Bernhard Payer
Eva Maria Novoa Pardo
Sara Sdelci
Renée Beekman

DUAL-AFFILIATED GROUPS

Marc A. Marti-Renom
Manuel Irimia
Donate Weghorn
Lars Velten

STAFF SCIENTISTS

Integrated in a senior research group, Staff Scientists support the research of the group, while having a degree of scientific independence to lead their own research line (i.e. co‐mentoring of PhD students, being senior authors in publications and applying for grants). As Faculty Members, Staff Scientists are evaluated every 4 years by an external committee composed of SAB and ad‐hoc members in the framework of the Programme’s evaluation.

Sergio Aranda Aragón
Sophie Bonnal

PROGRAMME STAFF