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PRBB-CRG Sessions Igor Ulitsky

PRBB-CRG Sessions Igor Ulitsky

24/01/2020
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PRBB-CRG Sessions Igor Ulitsky

MARIE CURIE

24/01/202012:00MARIE CURIEPRBB-CRG SessionsIgor UlitskyWeizmann Institute of Science, Rehovot, IL"Functions and modes of action of long noncoding RNAs in mammalian cells"Host: Jorge FerrerAbstract:We are interested in understanding the codes that drive the functions of long noncoding RNAs (lncRNAs) in mammalian cells. It is now well appreciated that the human genome encodes tens of thousands of distinct lncRNA transcripts, and an increasing number are implicated as regulators in critical pathways in health and disease. The mechanisms underlying their activity, to what extent these rely on specific sequences or structures, and how they are encoded in the genome remains largely unknown. I will describe our studies of lncRNA biology, which combine computational analysis of lncRNAs across vertebrates, high-throughput screens of lncRNA sequences for specific capabilities, and mouse models of lncRNA loss-of-function.