Roni Helene Grace Wright

Roni Helene Grace WrightRoni Helene Grace Wright

Beato Lab

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Beato Lab
Chromatin and Gene Expression
Staff Scientist
Roni Helene Grace Wright

Beato Lab

Chromatin and Gene Expression
Staff Scientist
Roni Helene Grace Wright

Short CV

2021 – Staff Scientist, Miguel Beato Lab, Centre Genomic Regulation (CRG), Barcelona (Spain)
2018 – Collaborating Professor, Health Sciences, Universitat International de Catalunya (UIC), Barcelona (Spain)
2009 – Postdoc, Miguel Beato Lab, Centre Genomic Regulation (CRG), Barcelona (Spain)
2009 – PhD Molecular Biology, University of Glasgow, Scotland (UK)
2006 – B.Sc. (hons), Biochemistry and Immunology, University of Strathclyde, Scotland (UK)

Summary

Despite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment of the primary tumor and occurs at a higher frequency in hormone receptor (Estrogen and Progesterone; HR+) positive breast cancers.

We have previously described the role of NUDT5 (Nudix-linked to moiety X-5) in HR+ breast cancer progression, specifically with regards to the growth of breast cancer stem cells (BCSCs). BCSCs are known to be the initiators of epithelial to mesenchyme transition (EMT), metastatic colonization and growth. Therefore, a greater understanding of the proteins and signaling pathways involved in the metastatic process may open the door for therapeutic opportunities.

My research focuses on understanding the mechanism of NUDT5 activation, analyzing signaling pathways and global gene expression datasets in 3D cell culture as a model for BCSCs. With the hope that this experimental approach may provide insight into novel crosstalk mechanisms for future drug discovery projects aiming to treat patients with aggressive cancer.

https://www.linkedin.com/in/roni-wright-she-her-206a00a?originalSubdomai...