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PRBB-CRG Sessions Simon Alberti

PRBB-CRG Sessions Simon Alberti

21/02/2020
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PRBB-CRG Sessions Simon Alberti

MARIE CURIE

21/02/202012:00MARIE CURIEPRBB-CRG SessionsSimon AlbertiMax Planck Institute of Molecular Cell Biology and Genetics (MPI-CBd), Dresden, Germany"Phase separation as an organizing principle in biology"Host: Sebastian MaurerAbstract:We aim to understand how cells change their internal organization upon environmental perturbations, stress and aging. Stressed cells undergo controlled changes on many levels to alter their physiology and metabolism. Many of these changes appear to directly result from alterations in the organization of the cytoplasm. Indeed, recent work from my lab shows that stressed cells form many membraneless compartments in the cytoplasm via a biochemical process known as phase separation. However, the initially beneficial ability to form such compartments becomes detrimental with increasing age, because compartment-forming tend to misfold and aggregate and thus are closely tied to aging and the pathogenesis associated with age-related diseases such as amyotrophic lateral sclerosis. Thus, recent efforts in the lab are focused on understanding the molecular links between cytoplasmic organization, membraneless compartments and age-related diseases.