You are here

    • You are here:
    • Home > Events > PRBB-CRG Sessions Mathieu Lupien

PRBB-CRG Sessions Mathieu Lupien

PRBB-CRG Sessions Mathieu Lupien

21/06/2019
Add to Calendar

PRBB-CRG Sessions Mathieu Lupien

MARIE CURIE

21/06/201912:00MARIE CURIEPRBB-CRG SessionsMathieu LupienPrincess Margaret Cancer Centre, CA"Partitioning the genome to find a role to noncoding mutations."Host: Donate Weghorn (CRG)Abstract:Difficulties in inferring the biological significance of noncoding mutations have limited their inclusion in precision genomics medicine pipelines. Most attempts to delineate a role for noncoding mutations relied on detecting evidence for positive selection within individual CREs, such as reported for the TERT gene promoter in a number of cancer types. However this approach dismisses the notion that the genome is more than a collection of individual functional elements. Instead, it consists of a network of functional elements that together delineate phenotype. Here, we present three different approaches to partition the genome into functional networks based on epigenetic features to increase our understanding of the role of noncoding mutations in cancer.