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PRBB-CRG Sessions Marcelo Guerín

PRBB-CRG Sessions Marcelo GuerínPRBB-CRG Sessions Marcelo Guerín

01/03/2024
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PRBB-CRG Sessions Marcelo Guerín

MARIE CURIE

01/03/202412:00MARIE CURIEPRBB-CRG SessionsMarcelo GuerínInstitute of Molecular Biology of Barcelona, IBMB-CSIC"Sculpting therapeutic monoclonal antibody N-glycans using endoglycosidases"Host: Carlo CarolisAbstract:Immunoglobulin G (IgG) monoclonal antibodies are a prominent and expanding class of therapeutics used for the treatment of diverse human disorders. The chemical composition of the N-glycan on the fragment crystallizable (Fc) region determines the effector functions through interaction with the Fc gamma receptors and complement proteins. The chemoenzymatic synthesis using endo-beta-N-acetylglucosaminidases (ENGases) emerged as a strategy to obtain antibodies with customized glycoforms that modulate their therapeutic activity. We will discuss the molecular mechanism by which ENGases recognize different N-glycans and protein substrates, especially those that are specific for IgG antibodies, in order to rationalize the glycoengineering of immunotherapeutic antibodies, which increase the impact on the treatment of myriad diseases.