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PRBB-CRG Sessions Satyajit Mayor

PRBB-CRG Sessions Satyajit Mayor

13/12/2019
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PRBB-CRG Sessions Satyajit Mayor

CHARLES DARWIN

13/12/201912:00CHARLES DARWINPRBB-CRG SessionsSatyajit MayorNational Centre for Biological Sciences (NCBS) &Tata Institute for Fundamental Research (TIFR), Bangalore, India"The skin of a living cell behaves as an active actin-membrane composite: mechanisms, functions and consequences"Host: Vivek Malhotra (CRG)Abstract:The plasma membrane of a living animal cell is a lipid bilayer, composed of a remarkably complex mixture of lipid species and proteins, draped over a dynamic cortical actin mesh. The composition of the lipid layer of a given cell type is reproducibly maintained, influencing the functioning of the plasma membrane. The way the cell maintains such a precise lipid composition is not fully understood; a variety of extrinsic and intrinsic factors including dietary inputs and synthetic capacities, respectively, could contribute. The cell also regulates the local composition of its membrane at the meso scale by actively controlling the formation of lipidic nano-domains. These nanodomains are templated at the cytoplasmic leaflet by juxta membrane acto-myosin machinery, linked via trans-bilayer linkages between lipid anchored proteins at the outer leaflet and phosphatidylserine at the inner leaflet. This active mechanism also results in a mesoscopic domain consisting of a clusters of nanodomains, an outcome of an active actin-membrane composite.

In my talk, I will describe recent findings on how a specific membrane receptor, the fibronectin-binding integrin receptor activates a signaling cascade which triggers actin polymerization and myosin activation, leading to the construction of these domains. Integrin-driven mechano-sensitive activation of the talin-vinculin axis is also necessary to build nano-domains. This results in the integration of both chemical and physical inputs to the integrin receptor via the construction of mechanoresponsive membrane domains, which participate in fine tuning receptor output and cellular scale phenomena.