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PRBB-CRG Sessions Benoit G. Bruneau

PRBB-CRG Sessions Benoit G. Bruneau

21/06/2019
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PRBB-CRG Sessions Benoit G. Bruneau

MARIE CURIE

21/06/201912:00MARIE CURIEPRBB-CRG SessionsBenoit G. BruneauGladstone Institute of Cardiovascular Disease, San Francisco, US“Epigenomic regulation of cardiac differentiation and development”Host: Cedric Notredame (CRG)Abstract:Networks of transcription factors and chromatin remodeling factors regulate cardiac cell fate and morphogenesis, and dominant mutations in these regulatory genes lead to congenital heart defects (CHDs). We have modeled haploinsufficiency of one such transcription factor, TBX5, in mice and in human iPS cells to attempt to understand CHD-related gene regulatory networks. I will also present data on the unusual roles of chromatin remodeling factors in establishing and maintaining cell fate, and preliminary efforts to delineate the initiating events in cardiogenesis.