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PRBB-CRG Sessions Adrian Bracken

PRBB-CRG Sessions Adrian BrackenPRBB-CRG Sessions Adrian Bracken

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PRBB-CRG Sessions Adrian Bracken


08/03/202412:00MARIE CURIEPRBB-CRG SessionsAdrian BrackenSmurfit Institute of Genetics, Trinity College Dublin"Interplay between PRC2 subcomplexes and canonical PRC1 in Development and Disease"Host: Luciano di CroceAbstract:In 2021, Professor Bracken was elected an EMBO Member for outstanding achievement in the life sciences. Since 2008, his lab has made several seminal discoveries in the field of chromatin and cancer biology. In particular, they provided key contributions to the understanding of the molecular mechanisms of how Polycomb Repressive Complexes regulate cell-fate decisions in stem cells and in cancer, e.g. Conway et al., Molecular Cell, 2018 and Healy et al. and Glancy et al., Molecular Cell, 2019 & 2023. The lab more recently studied an incurable childhood cancer called ‘H3-K27M-mutant diffuse midline glioma’ and demonstrated that EZH2 inhibitor drugs are a mechanistically anchored treatment strategy, based on modelling the consequences of the H3-K27M oncogene on the underlying biology (Brien et al., Nature Genetics, 2021). This talk will focus on new unpublished work on Polycomb complex functions in stem cells and cancer.