You are here

    • You are here:
    • Home > Events > Cell and Developmental Biology Programme Jan Brugues

Cell and Developmental Biology Programme Jan Brugues

Cell and Developmental Biology Programme Jan BruguesCell and Developmental Biology Programme Jan Brugues

25/05/2022
Add to Calendar

Cell and Developmental Biology Programme Jan Brugues

473.10

25/05/202210:00473.10Cell and Developmental Biology ProgrammeJan BruguesGroup Leader, MPI of Molecular Cell Biology and Genetics, MPI for Physics of Complex SystemsPhysics of intracellular self-organisation.Host: Malhotra, VivekAbstract:The formation of cellular compartments is essential for basic functions such as gene expression or cell division. How these compartments emerge from the collective behavior and activities of individual molecules is not well understood. In this talk, I will give an overview of the progress we made on uncovering principles of self-organization in cells using the mitotic spindle and chromatin as model systems. First I will describe how the size and shape of spindles arise from the interplay of mechanics, microtubule nucleation, and motor activities, and how these properties are regulated during early development. Then, I will show how capillary forces driven by transcription factors can lead to the emergence of DNA condensates, providing a new physical principle that could explain how distant DNA sequences meet to initiate and regulate transcription in the nucleus. Finally, I will give some outlook on novel approaches we are considering to further interrogate the connection between molecular activities and emergent properties in cells.